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Evaluation of gingival crevicular fluid transforming growth factor-1 level after treatment of intrabony periodontal defects with enamel matrix derivatives and autogenous bone graft: A randomized controlled clinical trial

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dc.contributor.authorYARAT, AYŞEN
dc.contributor.authorsAgrali, O. B.; Kuru, B. E.; Yarat, A.; Kuru, L.
dc.date.accessioned2022-03-12T20:27:17Z
dc.date.available2022-03-12T20:27:17Z
dc.date.issued2016
dc.description.abstractAim: The present study aimed to evaluate the effects of enamel matrix derivatives (EMD) either alone or combined with autogenous bone graft (ABG) applied to intrabony defects in chronic periodontitis patients on clinical/radiographic parameters and gingival crevicular fluid (GCF) transforming growth factor-1 (TGF-1) level and to compare with open flap debridement (OFD). Materials and Methods: A total of 30 deep intrabony defects in 12 patients were randomly treated with EMD + ABG (combination group), EMD alone (EMD group), or OFD (control group). Clinical parameters, including plaque index, gingival index, bleeding on probing, probing depth, relative attachment level, and recession were recorded at baseline and 6 months postsurgery. Intrabony defect fill percentage was calculated on the standardized radiographs. TGF-1 level was evaluated in GCF just before surgery and 7, 14, 30, 90, 180 days after surgery using enzyme-linked immunosorbent assay. Results: All treatment procedures led to significant improvements at 6 months (P 0.01). Gain in attachment level (P 0.01) and radiographic defect fill (P 0.05) of the combination and EMD groups were found to be significantly higher than those of the control group, while the use of EMD either with ABG or alone was observed to produce significantly less recession than the OFD (P 0.05). Conclusion: The findings suggest no clinical and radiographic differences between the combination and EMD groups whereas GCF TGF-1 level demonstrates an increase during the healing phase and is positively affected from EMD.
dc.identifier.doi10.4103/1119-3077.183306
dc.identifier.issn1119-3077
dc.identifier.pubmed27251974
dc.identifier.urihttps://hdl.handle.net/11424/233661
dc.identifier.wosWOS:000378282700020
dc.language.isoeng
dc.publisherMEDKNOW PUBLICATIONS & MEDIA PVT LTD
dc.relation.ispartofNIGERIAN JOURNAL OF CLINICAL PRACTICE
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAutogenous bone graft
dc.subjectchronic periodontitis
dc.subjectenamel matrix derivatives gingival crevicular fluid
dc.subjectperiodontal bone loss
dc.subjectperiodontal flap surgery
dc.subjecttransforming growth factor
dc.subjectGUIDED TISSUE REGENERATION
dc.subjectBOVINE-DERIVED XENOGRAFT
dc.subjectOSSEOUS DEFECTS
dc.subjectTGF-BETA
dc.subjectINTRAOSSEOUS DEFECTS
dc.subjectBIOACTIVE GLASS
dc.subjectINFRABONY DEFECTS
dc.subjectGENE-EXPRESSION
dc.subjectPROTEINS
dc.subjectHUMANS
dc.titleEvaluation of gingival crevicular fluid transforming growth factor-1 level after treatment of intrabony periodontal defects with enamel matrix derivatives and autogenous bone graft: A randomized controlled clinical trial
dc.typearticle
dspace.entity.typePublication
local.avesis.id19b24fc9-ddbc-4014-a2e3-53ff164624b5
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages9
local.journal.quartileQ4
oaire.citation.endPage543
oaire.citation.issue4
oaire.citation.startPage535
oaire.citation.titleNIGERIAN JOURNAL OF CLINICAL PRACTICE
oaire.citation.volume19
relation.isAuthorOfPublication46115086-6b46-4ef8-aaf1-ab8eda3e917e
relation.isAuthorOfPublication.latestForDiscovery46115086-6b46-4ef8-aaf1-ab8eda3e917e

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