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Proteomic Analysis of Liver Preservation Solutions Prior to Liver Transplantation

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dc.contributor.authorKAZAN, DİLEK
dc.contributor.authorsCoskun, Abdurrahman; Baykal, Ahmet Tarik; Oztug, Merve; Kazan, Dilek; Kaya, Ekrem; Emiroglu, Remzi; Yilmaz, Sezai; Dundar, Halit Ziya; Akgoz, Muslum; Berber, Ibrahim; Ak-tas, Hikmet; Bilsel, Gokhan; Karaosmanoglu, Kubra; Cetiner, Banu; Arslan, Cansu; Yurtsever, Ilknur; Yazici, Cevat
dc.date.accessioned2022-03-12T22:39:27Z
dc.date.available2022-03-12T22:39:27Z
dc.date.issued2019
dc.description.abstractObjective: Transplantation is the preferred treatment for patients with end-stage liver diseases. However, in clinical practice, functional preservation of the liver is a major concern before the transplantation. Although various protective solutions are used (in combination with hypothermia), the functional preservation time for liver is still limited to hours. We analyzed the preservation medium to detect the proteins released from the liver during storage period. Material/Methods: Samples were collected from the pre-transplant preservation mediums of 23 liver donors. For all donors, the cases involved Donation after Brain Death (DBD). 2D-PAGE and LCMSMS methodologies were used to detect the proteins and peptides from the preservation mediums. Results: A total of 198 proteins originating from the liver were detected. Conclusion: The data provide valuable insights into biomarkers that may be used to evaluate organ injury, functional status, and suitability for transplantation. Additionally, the findings could be valuable for the development of new strategies for effective preservation of solid organs prior to transplantation.
dc.identifier.doi10.2174/1570164615666180905104543
dc.identifier.eissn1875-6247
dc.identifier.issn1570-1646
dc.identifier.urihttps://hdl.handle.net/11424/235827
dc.identifier.wosWOS:000458615900004
dc.language.isoeng
dc.publisherBENTHAM SCIENCE PUBL LTD
dc.relation.ispartofCURRENT PROTEOMICS
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectLiver
dc.subjectmass spectrometry
dc.subjectorgan preservation solution
dc.subjectproteomics
dc.subjectliver transplantation
dc.subjecthypothermia
dc.subjectISCHEMIA-REPERFUSION INJURY
dc.subjectGLUTATHIONE-S-TRANSFERASE
dc.subjectGRAFT FUNCTION
dc.subjectCOLD ISCHEMIA
dc.subjectUW SOLUTION
dc.subjectEXPRESSION
dc.subjectARGINASE
dc.subjectENZYME
dc.subjectALPHA
dc.subjectCELLS
dc.titleProteomic Analysis of Liver Preservation Solutions Prior to Liver Transplantation
dc.typearticle
dspace.entity.typePublication
local.avesis.id74dc9880-4454-47e0-aece-9cf82b64a93b
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages17
local.journal.quartileQ4
oaire.citation.endPage135
oaire.citation.issue2
oaire.citation.startPage119
oaire.citation.titleCURRENT PROTEOMICS
oaire.citation.volume16
relation.isAuthorOfPublication3972a0fe-adf3-4da2-b289-7f01f80e3689
relation.isAuthorOfPublication.latestForDiscovery3972a0fe-adf3-4da2-b289-7f01f80e3689

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