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Pancreaticoduodenectomy in patients < 75 years versus ≥ 75 years old: a comparative study

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dc.contributor.authorERGENÇ, MUHAMMER
dc.contributor.authorUPRAK, TEVFİK KIVILCIM
dc.contributor.authorKARPUZ, ŞAKİR
dc.contributor.authorCOŞKUN, MÜMİN
dc.contributor.authorYEGEN, ŞEVKET CUMHUR
dc.contributor.authorATICI, ALİ EMRE
dc.contributor.authorsERGENÇ M., UPRAK T. K., Özocak A. B., KARPUZ Ş., COŞKUN M., YEGEN Ş. C., ATICI A. E.
dc.date.accessioned2024-08-01T06:39:24Z
dc.date.available2024-08-01T06:39:24Z
dc.date.issued2024-12-01
dc.description.abstractObjective: This study aimed to compare the postoperative outcomes of < 75-year-old patients and ≥ 75-year-old patients who underwent pancreaticoduodenectomy (PD) for pancreatic head and periampullary region tumors. Methods: Patients who underwent PD in our hospital between February 2019 and December 2023 were evaluated. Demographics, Eastern Cooperative Oncology Group Performance Status (ECOG-PS) scores, American Society of Anesthesiologists (ASA) scores, comorbidities, hospital stays, complications, and clinicopathological features were analyzed. Patients were divided into < 75 years (Group A) and ≥ 75 years (Group B) groups and compared. Results: The median age of the entire cohort (n = 155) was 66 years (IQR = 16). There was a significant difference between Group A (n = 128) and Group B (n = 27) regarding the ECOG-PS and ASA scores. There was no significant difference between the groups regarding postoperative complications. The 30-day mortality rate was greater in Group B (p = 0.017). Group B had a cumulative median survival of 10 months, whereas Group A had a median survival of 28 months, with a statistically significant difference (p < 0.001). When age groups were stratified according to ECOG-PS, for ECOG-PS 2–3 Group A, survival was 15 months; for ECOG-PS 2–3 Group B, survival was eight months, and the difference was not statistically significant (p = 0.628). Conclusions: With the increasing aging population, patient selection for PD should not be based solely on age. This study demonstrated that PD is safe for patients older than 75 years. In older patients, performance status and the optimization of comorbidities should be considered when deciding on a candidate’s suitability for surgery.
dc.identifier.citationERGENÇ M., UPRAK T. K., Özocak A. B., KARPUZ Ş., COŞKUN M., YEGEN Ş. C., ATICI A. E., "Pancreaticoduodenectomy in patients < 75 years versus ≥ 75 years old: a comparative study", Aging Clinical and Experimental Research, cilt.36, sa.1, 2024
dc.identifier.doi10.1007/s40520-024-02804-9
dc.identifier.issn1594-0667
dc.identifier.issue1
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85197477052&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/297348
dc.identifier.volume36
dc.language.isoeng
dc.relation.ispartofAging Clinical and Experimental Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectGeriatri
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectSağlık Bilimleri
dc.subjectTemel Bilimler
dc.subjectMedicine
dc.subjectInternal Medicine Sciences
dc.subjectInternal Diseases
dc.subjectGeriatrics
dc.subjectLife Sciences
dc.subjectMolecular Biology and Genetics
dc.subjectCytogenetic
dc.subjectHealth Sciences
dc.subjectNatural Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectKlinik Tıp
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.subjectGERİATRİ ve GERONTOLOJİ
dc.subjectClinical Medicine (MED)
dc.subjectLife Sciences (LIFE)
dc.subjectCLINICAL MEDICINE
dc.subjectMOLECULAR BIOLOGY & GENETICS
dc.subjectBIOCHEMISTRY & MOLECULAR BIOLOGY
dc.subjectGERIATRICS & GERONTOLOGY
dc.subjectYaşlanma
dc.subjectGeriatri ve Gerontoloji
dc.subjectAging
dc.subjectGeriatrics and Gerontology
dc.subjectElderly
dc.subjectGeriatric surgery
dc.subjectPancreatectomy
dc.subjectPancreatic adenocarcinoma
dc.subjectPerformance status
dc.subjectSurvival
dc.titlePancreaticoduodenectomy in patients < 75 years versus ≥ 75 years old: a comparative study
dc.typearticle
dspace.entity.typePublication
local.avesis.iddb36bea2-4678-458b-ad3a-b23f3e5d87a1
local.indexed.atPUBMED
local.indexed.atSCOPUS
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