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Protective effect of beta-glucan against oxidative organ injury in a rat model of sepsis

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dc.contributor.authorERCAN, FERİHA
dc.contributor.authorsSener, G; Toklu, H; Ercan, F; Erkanli, G
dc.date.accessioned2022-03-12T17:19:13Z
dc.date.available2022-03-12T17:19:13Z
dc.date.issued2005
dc.description.abstractSepsis leads to various organ damage and dysfunction. One of the underlying mechanisms is thought to be the oxidative damage due to the generation of free radicals. In this study, we investigated the putative protective role of beta-gluican against sepsis-induced oxidative organ damage. Sepsis was induced by caecal ligation and puncture (CLP) in Wistar albino rats. Sham operated (control) and sepsis groups received saline or beta-glucan (50 mg/kg, po) once daily for 10 days and 30 min prior to and 6 h after the CLP. Sixteen hours after the surgery, rats were decapitated and the biochemical changes were determined in the brain, diaphragm, kidney, heart, liver and lung tissues using malondialdehyde (N4DA) content - an index of lipid peroxidation - glutathione (GSH) levels - a key antioxidant - and myeloperoxidase (MPO) activity - an index of neutrophil infiltration. Serum TNF-alpha levels were assessed by RIA method. Tissues were also examined under light microscope to evaluate the degree of sepsis-induced damage. The results demonstrate that sepsis significantly decreased GSH levels and increased the MDA levels and MPO activity (p < 0.05-p < 0.001) causing oxidative damage. Elevated plasma TNF-alpha levels in septic rats significantly reduced to control levels in beta-glucan treated rats. Since -glucan administration reversed these oxidant responses, it seems likely that beta-glucan protects against sepsis-induced oxidative organ injury. (c) 2005 Elsevier B.V. All rights reserved.
dc.identifier.doi10.1016/j.intimp.2005.03.007
dc.identifier.eissn1878-1705
dc.identifier.issn1567-5769
dc.identifier.pubmed15953565
dc.identifier.urihttps://hdl.handle.net/11424/228076
dc.identifier.wosWOS:000230216200004
dc.language.isoeng
dc.publisherELSEVIER
dc.relation.ispartofINTERNATIONAL IMMUNOPHARMACOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectsepsis.
dc.subjectbeta-glucan
dc.subjectlipid peroxidation
dc.subjectglutathione
dc.subjectmyeloperoxidase activity
dc.subjectTNF-alpha
dc.subjectMYELOPEROXIDASE ACTIVITY
dc.subjectFREE-RADICALS
dc.subjectACTIVATION
dc.subjectMELATONIN
dc.subjectRECEPTOR
dc.subjectEXPRESSION
dc.subjectTISSUE
dc.subjectGLUTATHIONE
dc.subjectCD11B/CD18
dc.subjectDECTIN-1
dc.titleProtective effect of beta-glucan against oxidative organ injury in a rat model of sepsis
dc.typearticle
dspace.entity.typePublication
local.avesis.id52f26705-bfe4-46cc-9326-f9773a81e992
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages10
oaire.citation.endPage1396
oaire.citation.issue9
oaire.citation.startPage1387
oaire.citation.titleINTERNATIONAL IMMUNOPHARMACOLOGY
oaire.citation.volume5
relation.isAuthorOfPublicationadc800ed-105c-40c7-a572-6cf3f175be92
relation.isAuthorOfPublication.latestForDiscoveryadc800ed-105c-40c7-a572-6cf3f175be92

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