Publication:
Investigation of Vitamin D Receptor Gene Polymorphism in Pediatric Patients with Brain Cancer

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dc.contributor.authorKOÇ, AHMET
dc.contributor.authorsYilmaz, Baris; Tokuc, Gulnur Ayse; Koc, Ahmet; Yesil, Edanur
dc.date.accessioned2022-03-12T20:31:37Z
dc.date.available2022-03-12T20:31:37Z
dc.date.issued2017
dc.description.abstractAim: In recent years, it is believed that Vitamin D may play a protective role in some cancer types. Certain regions of the Vitamin D receptor (VDR) gene may show a genetic difference in structure. The most frequent polymorphisms in this gene are in Taq-1, Fok-1, and Bsm-1 regions. Some adult cancer types are associated with VDR gene polymorphism such as; colorectal carcinoma, breast carcinoma, and prostate carcinoma. Reviewing the medical literature, no such study had been done on children so far. Materials and Methods: We investigated the association of the three most common gene polymorphisms (Taq-1, Fok-1, and Bsm-1 regions) in VDR gene in 32 children with brain tumors and forty control healthy volunteers. Results: We could not find any relationship between childhood brain tumors and VDR gene polymorphism in these three regions. Conclusion: The present results suggest that the Taq-1, Fok-1, and Bsm-1 polymorphism in the VDR gene and pediatric brain cancers have no association.
dc.identifier.doi10.4103/ijmpo.ijmpo_22_16
dc.identifier.eissn0975-2129
dc.identifier.issn0971-5851
dc.identifier.pubmed28900319
dc.identifier.urihttps://hdl.handle.net/11424/234309
dc.identifier.wosWOS:000407909300006
dc.language.isoeng
dc.publisherTHIEME MEDICAL PUBL INC
dc.relation.ispartofINDIAN JOURNAL OF MEDICAL AND PAEDIATRIC ONCOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBrain cancers
dc.subjectchildhood
dc.subjectpolymorphism
dc.subjectVitamin D receptor
dc.subject1,25-DIHYDROXYVITAMIN D-3
dc.subjectCOLORECTAL-CANCER
dc.subjectCELL-DEATH
dc.subjectPREVENTION
dc.subjectGROWTH
dc.subjectTRANSCRIPTION
dc.subjectINHIBITION
dc.subjectMORTALITY
dc.subjectTHERAPY
dc.subjectRISK
dc.titleInvestigation of Vitamin D Receptor Gene Polymorphism in Pediatric Patients with Brain Cancer
dc.typearticle
dspace.entity.typePublication
local.avesis.id580cd48d-9404-4c2f-bb69-4d2f67202868
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages5
oaire.citation.endPage132
oaire.citation.issue2
oaire.citation.startPage128
oaire.citation.titleINDIAN JOURNAL OF MEDICAL AND PAEDIATRIC ONCOLOGY
oaire.citation.volume38
relation.isAuthorOfPublication41bfa1f1-f3ed-4d4b-9e02-902fd20bc830
relation.isAuthorOfPublication.latestForDiscovery41bfa1f1-f3ed-4d4b-9e02-902fd20bc830

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