Publication:
The Effect of Stinging Nettle (Urtica dioica) Seed Oil on Experimental Colitis in Rats

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dc.contributor.authorYARAT, AYŞEN
dc.contributor.authorsGenc, Zeynep; Yarat, Aysen; Tunali-Akbay, Tugba; Sener, Goksel; Cetinel, Sule; Pisiriciler, Rabia; Caliskan-Ak, Esin; Altintas, Ayhan; Demirci, Betul
dc.date.accessioned2022-03-12T17:51:39Z
dc.date.available2022-03-12T17:51:39Z
dc.date.issued2011
dc.description.abstractThis study investigated the effect of Urtica dioica, known as stinging nettle, seed oil (UDO) treatment on colonic tissue and blood parameters of trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats. Experimental colitis was induced with 1mL of TNBS in 40% ethanol by intracolonic administration with a 8-cm-long cannula with rats under ether anesthesia, assigned to a colitis group and a colitis + UDO group. Rats in the control group were given saline at the same volume by intracolonic administration. UDO (2.5mL/kg) was given to the colitis + UDO group by oral administration throughout a 3-day interval, 5 minutes later than colitis induction. Saline (2.5 mL/kg) was given to the control and colitis groups at the same volume by oral administration. At the end of the experiment macroscopic lesions were scored, and the degree of oxidant damage was evaluated by colonic total protein, sialic acid, malondialdehyde (MDA), and glutathione levels, collagen content, tissue factor activity, and superoxide dismutase and myeloperoxidase activities. Colonic tissues were also examined by histological and cytological analysis. Pro-inflammatory cytokines (tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6), lactate dehydrogenase activity, and triglyceride and cholesterol levels were analyzed in blood samples. We found that UDO decreased levels of pro-inflammatory cytokines, lactate dehydrogenase, triglyceride, and cholesterol, which were increased in colitis. UDO administration ameliorated the TNBS-induced disturbances in colonic tissue except for MDA. In conclusion, UDO, through its anti-inflammatory and antioxidant actions, merits consideration as a potential agent in ameliorating colonic inflammation.
dc.identifier.doi10.1089/jmf.2011.0028
dc.identifier.issn1096-620X
dc.identifier.pubmed21861725
dc.identifier.urihttps://hdl.handle.net/11424/230317
dc.identifier.wosWOS:000298145500010
dc.language.isoeng
dc.publisherMARY ANN LIEBERT, INC
dc.relation.ispartofJOURNAL OF MEDICINAL FOOD
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectantioxidant-oxidant system
dc.subjectcolitis
dc.subjectsialic acid
dc.subjecttissue factor activity
dc.subjectUrtica dioica
dc.subjectINFLAMMATORY-BOWEL-DISEASE
dc.subjectTUMOR-NECROSIS-FACTOR
dc.subjectULCERATIVE-COLITIS
dc.subjectFREE-RADICALS
dc.subjectTISSUE FACTOR
dc.subjectCOLONIC INFLAMMATION
dc.subjectLIPID-PEROXIDATION
dc.subjectNIGELLA-SATIVA
dc.subjectSIALIC ACIDS
dc.subjectIN-VITRO
dc.titleThe Effect of Stinging Nettle (Urtica dioica) Seed Oil on Experimental Colitis in Rats
dc.typearticle
dspace.entity.typePublication
local.avesis.idc293c427-3857-4ac3-a6b8-055f55fd1297
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages8
oaire.citation.endPage1561
oaire.citation.issue12
oaire.citation.startPage1554
oaire.citation.titleJOURNAL OF MEDICINAL FOOD
oaire.citation.volume14
relation.isAuthorOfPublication46115086-6b46-4ef8-aaf1-ab8eda3e917e
relation.isAuthorOfPublication.latestForDiscovery46115086-6b46-4ef8-aaf1-ab8eda3e917e

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