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Melatonin protects against oxidative organ injury in a rat model of sepsis

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dc.contributor.authorYEGEN, BERRAK
dc.contributor.authorsSener, G; Toklu, H; Kapucu, C; Ercan, F; Erkanli, G; Kacmaz, A; Tilki, M; Yegen, BC
dc.date.accessioned2022-03-12T17:20:20Z
dc.date.available2022-03-12T17:20:20Z
dc.date.issued2005
dc.description.abstractPurpose. Based on the potent antioxidant effects of melatonin, we investigated the putative protective role of melatonin against sepsis-induced oxidative organ damage in rats. Methods. Sepsis was induced by cecal ligation and puncture (CLP) in Wistar albino rats. Animals subjected to CLP and sham-operated control rats were given saline or melatonin 10 mg/kg intraperitoneally 30 min before and 6 h after the operation. The rats were killed 16 h after the operation and the biochemical changes were investigated in the liver, kidney, heart, lung, diaphragm, and brain tissues by examining malondialdehyde (MDA) and glutathione (GSH) levels, and myeloperoxidase (MPO) activity. We also examined the tissues microscopically. Results. Sepsis resulted in a significant decrease in GSH levels and a significant increase in MDA levels and MPO activity (P < 0.05-P < 0.001) showing oxidative damage, which was confirmed by histological examination. Melatonin clearly reversed these oxidant responses and the microscopic damage, demonstrating its protective effects against sepsis-induced oxidative organ injury. Conclusion. The increase in MDA levels and MPO activity and the concomitant decrease in GSH levels demonstrate the role of oxidative mechanisms in sepsis-induced tissue damage. Melatonin, by its free radical scavenging and antioxidant properties, ameliorated oxidative organ injury. Thus, supplementing antiseptic shock treatment with melatonin may be beneficial in the clinical setting.
dc.identifier.doi10.1007/s00595-004-2879-1
dc.identifier.eissn1436-2813
dc.identifier.issn0941-1291
dc.identifier.pubmed15622465
dc.identifier.urihttps://hdl.handle.net/11424/228224
dc.identifier.wosWOS:000225961600010
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofSURGERY TODAY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectsepsis
dc.subjectmelatonin
dc.subjectlipid peroxidation
dc.subjectglutathione
dc.subjectmyeloperoxidase activity
dc.subjectISCHEMIA-REPERFUSION
dc.subjectFREE-RADICALS
dc.subjectNITRIC-OXIDE
dc.subjectINFLAMMATION
dc.subjectGLUTATHIONE
dc.subjectDAMAGE
dc.subjectMYELOPEROXIDASE
dc.subjectENDOTHELIUM
dc.subjectPERITONITIS
dc.subjectDYSFUNCTION
dc.titleMelatonin protects against oxidative organ injury in a rat model of sepsis
dc.typearticle
dspace.entity.typePublication
local.avesis.id7e10a575-e752-4ed8-9b1b-1075f82435f2
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages8
oaire.citation.endPage59
oaire.citation.issue1
oaire.citation.startPage52
oaire.citation.titleSURGERY TODAY
oaire.citation.volume35
relation.isAuthorOfPublicatione4eaf9ac-f8dc-4e2b-b940-895cc906790d
relation.isAuthorOfPublication.latestForDiscoverye4eaf9ac-f8dc-4e2b-b940-895cc906790d

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