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Immunosuppression of HLA identical living-donor kidney transplant recipients: A systematic review

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dc.contributor.authorVELİOĞLU, ARZU
dc.contributor.authorsPérez-Sáez M. J., Montero N., Oliveras L., Redondo-Pachón D., Martínez-Simón D., Abramovicz D., Maggiore U., Mariat C., Mjoen G., Oniscu G. C., et al.
dc.date.accessioned2023-09-12T13:23:10Z
dc.date.available2023-09-12T13:23:10Z
dc.date.issued2023-12-01
dc.description.abstractBackground: Kidney transplant (KT) recipients of HLA identical siblings (HLAid) have lower immunological risk, but there are no specific recommendations for immunosuppression. Our aim was to analyze evidence about results from HLAid living-donor recipients under different immunosuppression in the current era of immunological risk assessment. Methods: Systematic review of studies describing associations between outcomes of HLAid living-donor KT recipients according to their immunological risk and applied immunosuppression. Results: From 1351 studies, 16 (5636 KT recipients) were included in the analysis. All studies were retrospective, ten comparing immunosuppression strategies, and six immunological risk strata. Of those ten, six studies were published in 1990 or earlier and only three included tacrolimus. The evidence is poor, and the inclusion of calcineurin inhibitors does not demonstrate better results. Furthermore, only few studies describe different immunosuppression regimens according to the patient immunological risk and, in general, they do not include the assessment with new solid phase assays. Conclusions: There are no studies analyzing the association of outcomes of HLAid KT recipients with current immunological risk tools. In the absence of evidence, no decision or proposal of immunosuppression adapted to modern immunological risk assessment can be made currently by the Descartes Working Group.
dc.identifier.citationPérez-Sáez M. J., Montero N., Oliveras L., Redondo-Pachón D., Martínez-Simón D., Abramovicz D., Maggiore U., Mariat C., Mjoen G., Oniscu G. C., et al., "Immunosuppression of HLA identical living-donor kidney transplant recipients: A systematic review", Transplantation Reviews, cilt.37, sa.4, 2023
dc.identifier.doi10.1016/j.trre.2023.100787
dc.identifier.issn0955-470X
dc.identifier.issue4
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85168820571&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/293305
dc.identifier.volume37
dc.language.isoeng
dc.relation.ispartofTransplantation Reviews
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectCerrahi Tıp Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectSurgery Medicine Sciences
dc.subjectHealth Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectTRANSPLANTASYON
dc.subjectCERRAHİ
dc.subjectClinical Medicine (MED)
dc.subjectCLINICAL MEDICINE
dc.subjectTRANSPLANTATION
dc.subjectSURGERY
dc.subjectCerrahi
dc.subjectTransplantasyon
dc.subjectSurgery
dc.subjectTransplantation
dc.subjectHLA-identical siblings
dc.subjectImmunological risk
dc.subjectImmunosuppression
dc.subjectLiving kidney donation
dc.subjectSingle HLA antigen beads
dc.titleImmunosuppression of HLA identical living-donor kidney transplant recipients: A systematic review
dc.typearticle
dspace.entity.typePublication
local.avesis.idb8b0c4ff-51f9-4153-971d-d3af34cb5d4f
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublicationa7410f0e-0eb4-4b83-ad61-a71dfbee164f
relation.isAuthorOfPublication.latestForDiscoverya7410f0e-0eb4-4b83-ad61-a71dfbee164f

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