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PROTECTIVE EFFECTS OF VORTIOXETINE IN PREDATOR SCENT STRESS MODEL OF POST-TRAUMATIC STRESS DISORDER IN RATS: ROLE ON NEUROPLASTICITY AND APOPTOSIS

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dc.contributor.authorYAVUZ, AYŞE NUR
dc.contributor.authorsOzbeyli, D.; Aykac, A.; Alaca, N.; Hazar-Yavuz, A. N.; Ozkan, N.; Sener, G.
dc.date.accessioned2022-03-12T22:38:41Z
dc.date.available2022-03-12T22:38:41Z
dc.date.issued2019
dc.description.abstractPost-traumatic stress disorder (PTSD) can be observed after a traumatic event. The effect of an antidepressant vortioxetine (Vrx) against PTSD is unknown. The aim of this study was to investigate the possible protective effect of Vrx in the predator scent-induced PTSD rat model. The rats were exposed to dirty cat litter for 10 min and the protocol was repeated 1 week later with clean cat litter as a trauma reminder. The rats received Vrx (10 mg/kg/p.o.) or saline (1 ml/kg/p.o.) during 7 days between two exposure sessions. Novel object recognition test, hole board test, and elevated plus maze were performed. The b-cell lymphoma (bcl-2)/bcl-2-associated X protein (bax) ratio, brain-derived neurotrophic factor (BDNF), caspase-3 and -9 expressions were detected using Western blotting in the amygdaloid complex, hippocampus, and frontal cortex. Our results indicate that increased freezing time and anxiety index in the stress-induced group is decreased with Vrx application. Vrx treatment improved deteriorated recognition memory in the stress-induced group. Decreased bcl-2/bax ratio and BDNF level and increased caspase-3 and -9 expressions in the stress group, improved with Vrx in the amygdala, and hippocampus. Decreased bcl-2/bax ratio and increased casp-3 and -9 expressions in the stress group are ameliorated with Vrx in frontal cortex. The level of BDNF was increased with Vrx in the frontal cortex. Increased damage scores in the amygdaloid complex, hippocampal CA3, and frontal cortex in the stress group ameliorated with Vrx treatment. Our results show that if vortioxetine is administered immediately after trauma, it reduces anxiety, cognitive and neuronal impairment and may be protective against the development of PTSD.
dc.identifier.doi10.26402/jpp.2019.4.07
dc.identifier.issn0867-5910
dc.identifier.pubmed31642818
dc.identifier.urihttps://hdl.handle.net/11424/235706
dc.identifier.wosWOS:000491933600007
dc.language.isoeng
dc.publisherPOLISH PHYSIOLOGICAL SOC
dc.relation.ispartofJOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectpost-traumatic stress disorder
dc.subjectvortioxetine
dc.subjectbrain-derived neurotrophic factor
dc.subjectapoptosis
dc.subjectrecognition memory
dc.subjectGENERALIZED ANXIETY DISORDER
dc.subjectMULTIMODAL ANTIDEPRESSANT
dc.subjectANIMAL-MODEL
dc.subjectHIPPOCAMPAL VOLUME
dc.subjectRECEPTOR SUBTYPES
dc.subjectLU AA21004
dc.subjectMEMORY
dc.subjectEXERCISE
dc.subjectEXPOSURE
dc.subjectAMYGDALA
dc.titlePROTECTIVE EFFECTS OF VORTIOXETINE IN PREDATOR SCENT STRESS MODEL OF POST-TRAUMATIC STRESS DISORDER IN RATS: ROLE ON NEUROPLASTICITY AND APOPTOSIS
dc.typearticle
dspace.entity.typePublication
local.avesis.id04d789fe-f6dd-452f-931d-99e1816b0b3f
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages15
local.journal.quartileQ2
oaire.citation.endPage571
oaire.citation.issue4
oaire.citation.startPage557
oaire.citation.titleJOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
oaire.citation.volume70
relation.isAuthorOfPublication0bd18078-950c-4d8c-93f6-120ce419897d
relation.isAuthorOfPublication.latestForDiscovery0bd18078-950c-4d8c-93f6-120ce419897d

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