Publication:
Enhanced Light-Driven Antimicrobial Activity of Cationic Poly(oxanorbornene)s by Phthalocyanine Incorporation into Polymer as Pendants

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dc.contributor.authorAKSU, MEHMET BURAK
dc.contributor.authorsAhmetali, Erem; Sen, Pinar; Suer, N. Ceren; Aksu, Burak; Nyokong, Tebello; Eren, Tarik; Sener, M. Kasim
dc.date.accessioned2022-03-12T22:44:07Z
dc.date.available2022-03-12T22:44:07Z
dc.date.issued2020
dc.description.abstractAmphiphilic poly(oxanorbornene)s are promising synthetic polymers that mimic the structural properties and antimicrobial functions of naturally occurring antimicrobial peptides. Here, poly(oxanorbornene)s bearing pendant zinc(II) phthalocyanine and triphenyl(ethyl) phosphonium functionalities are synthesized by ring-opening metathesis polymerization (ROMP). Fluorescence, singlet oxygen and triplet quantum yields of polymers are measured in dimethyl sulfoxide and aqueous medium. The singlet oxygen quantum yields of copolymers with the highest triphenyl and triethyl phosphonium content are found to be 0.29 and 0.41, respectively. Then, antimicrobial activities of polymers against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) are investigated under both dark and light conditions. Synergistic effect of zinc(II) phthalocyanine and phosphonium-containing poly(oxanorbornene) is observed that the conjugate possessing the most triphenyl phosphonium side chains has the highest activity under light against both gram-positive and gram-negative bacterial strains after 80 min irradiation, reducing the survival of E. coli or S. aureus by 99.9999%. Hemolytic concentrations of the copolymers are found between 8 and 512 mu g mL(-1). Scanning electron microscopy (SEM) proves that the bacteria membrane deforms after contacting with the biocidal polymer.
dc.identifier.doi10.1002/macp.202000386
dc.identifier.eissn1521-3935
dc.identifier.issn1022-1352
dc.identifier.urihttps://hdl.handle.net/11424/236397
dc.identifier.wosWOS:000591336500001
dc.language.isoeng
dc.publisherWILEY-V C H VERLAG GMBH
dc.relation.ispartofMACROMOLECULAR CHEMISTRY AND PHYSICS
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectmacromolecular photosensitizers
dc.subjectPACT
dc.subjectphthalocyanine
dc.subjectpoly(oxanorbornene)
dc.subjectROMP
dc.subjectsinglet oxygen
dc.subjectPHOTODYNAMIC THERAPY
dc.subjectSINGLET OXYGEN
dc.subjectPHOTOPHYSICAL PROPERTIES
dc.subjectZINC(II) PHTHALOCYANINE
dc.subjectSYNTHETIC MIMICS
dc.subjectANTIBACTERIAL
dc.subjectROMP
dc.subjectPHOTOOXIDATION
dc.subjectSUBSTITUENTS
dc.subjectAGGREGATION
dc.titleEnhanced Light-Driven Antimicrobial Activity of Cationic Poly(oxanorbornene)s by Phthalocyanine Incorporation into Polymer as Pendants
dc.typearticle
dspace.entity.typePublication
local.avesis.ida1770033-d4b0-4ddf-b103-98285235f469
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.articlenumber2000386
local.journal.numberofpages14
local.journal.quartileQ3
oaire.citation.issue24
oaire.citation.titleMACROMOLECULAR CHEMISTRY AND PHYSICS
oaire.citation.volume221
relation.isAuthorOfPublicationf7de5699-7a5c-4496-93cf-d8daba79da4f
relation.isAuthorOfPublication.latestForDiscoveryf7de5699-7a5c-4496-93cf-d8daba79da4f

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