Publication:
Controlled delivery of amoxicillin and rifampicin by three-dimensional polyvinyl alcohol/bismuth ferrite scaffolds

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dc.contributor.authorULAĞ, SONGÜL
dc.contributor.authorŞAHİN, ALİ
dc.contributor.authorsIlgar S., ULAĞ S., ŞAHİN A., GÜNDÜZ O., Ustundag C. B.
dc.date.accessioned2023-05-22T08:13:17Z
dc.date.available2023-05-22T08:13:17Z
dc.date.issued2023-05-01
dc.description.abstractSkin is a protective barrier that can protect against environmental influences and renew itself. However, in some cases, this regenerative property is lost, and this causes delays in wound healing. Wound healing is a complex and long-lasting phase. Any bacterial infection during the wound healing process delays wound healing. The therapeutic efficacy can be increased by using nanocarrier drug delivery systems to the target tissue with modern wound dressings. Controlled nano drug delivery systems increase the therapeutic efficacy in the treatment of diseases and provide a faster recovery process. In this study, amoxicillin (AMX) and rifampicin (RIF) were loaded into the bismuth ferrite (BFO) particles which were synthesized with the co-precipitation method. Then, these drug-loaded BFO particles (0.075 %) were added separately to 13 % polyvinyl alcohol (PVA) solution and the solutions were printed three-dimensionally to obtain three dimensional scaffolds. With these designed scaffolds, it is aimed to reduce the risk of inflammation in wound tissues and increase therapeutic efficacy with controlled release. The SEM images proved that homogeneous pore distributions could be achieved with these combinations. The tensile test results showed that drug-loaded BFO addition increased the mechanical strength of the 13 % PVA scaffold. The biocompatibility test results demonstrated that the highest viability values of the human adipose tissue-derived mesenchymal stem cells were obtained for AMX-added 13 % PVA scaffolds.
dc.identifier.citationIlgar S., ULAĞ S., ŞAHİN A., GÜNDÜZ O., Ustundag C. B., "Controlled Delivery of Amoxicillin and Rifampicin by Three-Dimensional Polyvinyl alcohol/Bismuth Ferrite Scaffolds", CHEMISTRYSELECT, cilt.8, sa.18, 2023
dc.identifier.doi10.1002/slct.202204798
dc.identifier.issn2365-6549
dc.identifier.issue18
dc.identifier.urihttps://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/slct.202204798
dc.identifier.urihttps://hdl.handle.net/11424/289503
dc.identifier.volume8
dc.language.isoeng
dc.relation.ispartofCHEMISTRYSELECT
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectKimya
dc.subjectBiyokimya
dc.subjectAlkoloidler
dc.subjectTemel Bilimler
dc.subjectChemistry
dc.subjectBiochemistry
dc.subjectAlcaloides
dc.subjectNatural Sciences
dc.subjectKİMYA, MULTİDİSİPLİNER
dc.subjectTemel Bilimler (SCI)
dc.subjectCHEMISTRY, MULTIDISCIPLINARY
dc.subjectCHEMISTRY
dc.subjectNatural Sciences (SCI)
dc.subjectKimya (çeşitli)
dc.subjectGenel Kimya
dc.subjectFizik Bilimleri
dc.subjectChemistry (miscellaneous)
dc.subjectGeneral Chemistry
dc.subjectPhysical Sciences
dc.subjectBismuth ferrite
dc.subjectcontrolled drug delivery
dc.subjectpolyvinyl alcohol
dc.subject3D printing
dc.subjectwound dressing
dc.subjectDRUG-DELIVERY
dc.subjectNANOPARTICLES
dc.subjectHYDROGELS
dc.subjectTISSUE
dc.subjectPVA
dc.subjectNANOCOMPOSITE
dc.titleControlled delivery of amoxicillin and rifampicin by three-dimensional polyvinyl alcohol/bismuth ferrite scaffolds
dc.typearticle
dspace.entity.typePublication
local.avesis.id13b6e359-8dda-441c-9274-de0d3585aa30
local.indexed.atWOS
relation.isAuthorOfPublication7694c253-e59a-4111-abfb-dcb9eed6d6f8
relation.isAuthorOfPublicationdda71138-8ce4-4265-89b2-73bc94786a4f
relation.isAuthorOfPublication.latestForDiscovery7694c253-e59a-4111-abfb-dcb9eed6d6f8

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