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Effectiveness of Recombinant Human Growth Hormone for Pharyngocutaneous Fistula Closure

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dc.contributor.authorBİNNETOĞLU, ADEM
dc.contributor.authorsKucuk, Nurten; Sari, Murat; Midi, Ahmet; Yumusakhuylu, Ali Cemal; Findik, Ozan; Binnetoglu, Adem
dc.date.accessioned2022-03-14T08:13:37Z
dc.date.available2022-03-14T08:13:37Z
dc.date.issued2015
dc.description.abstractObjectives. In laryngeal cancer, which comprises 25% of head and neck cancer, chemotherapy has come into prominence with the increase in organ-protective treatments. With such treatment, salvage surgery has increased following recurrence; the incidence of pharyngocutaneous fistula has also increased in both respiratory and digestive system surgery We investigated the effects of recombinant human growth hormone on pharyngocutaneous fistula closure in Sprague-Dawley rats, based on an increase in amino acid uptake and protein synthesis for wound healing, an increase in mitogenesis, and enhancement of collagen formation by recombinant human growth hormone. Methods. This study was experimental animal study. Forty Sprague-Dawley rats were separated into two groups, and pharyngoesophagotomy was perfouned. The pharyngoesophagotomy was sutured with vicryl in both groups. Rats in group 1 (control group) received no treatment, while those in group 2 were administered a subcutaneous injection of recombinant human growth hormone daily. On day 14, the pharynx, larynx, and upper oesophagus were excised and examined microscopically. Results. Pharyngocutaneous fistula exhibited better closure macroscopically in the recombinant human growth hormone group. There was a significant difference in collagen formation and epithelisation in the recombinant human growth hormone group compared to the control group. Conclusion. This study is believed to be the first in which the effect of recombinant human growth hormone on pharyngocutaneous fistula closure was evaluated, and the findings suggest the potential of use of growth hormone for treatment of pharyngocutaneous fistula.
dc.identifier.doi10.3342/ceo.2015.8.4.390
dc.identifier.eissn2005-0720
dc.identifier.issn1976-8710
dc.identifier.pubmed26622960
dc.identifier.urihttps://hdl.handle.net/11424/241109
dc.identifier.wosWOS:000367117700015
dc.language.isoeng
dc.publisherKOREAN SOC OTORHINOLARYNGOL
dc.relation.ispartofCLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPharyngocutaneous Fistula
dc.subjectRecombinant Human Growth Hormone
dc.subjectPostoperative Laryngectomy Complications
dc.subjectLARYNGECTOMY
dc.subjectRATS
dc.subjectCHILDREN
dc.subjectCANCER
dc.subjectBONE
dc.titleEffectiveness of Recombinant Human Growth Hormone for Pharyngocutaneous Fistula Closure
dc.typearticle
dspace.entity.typePublication
local.avesis.id79545465-80fd-4b7a-87d1-50689322c7fa
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages6
oaire.citation.endPage395
oaire.citation.issue4
oaire.citation.startPage390
oaire.citation.titleCLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY
oaire.citation.volume8
relation.isAuthorOfPublication7d22b68b-082d-4ffc-95cf-2646bb131363
relation.isAuthorOfPublication.latestForDiscovery7d22b68b-082d-4ffc-95cf-2646bb131363

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