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The effect of polycaprolactone/graphene oxide electrospun scaffolds on the neurogenic behavior of adipose stem cells

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dc.contributor.authorŞAHİN, ALİ
dc.contributor.authorsPinar E., Sahin A., Unal S., Gunduz O., Harman F., Kaptanoglu E.
dc.date.accessioned2022-03-23T11:41:28Z
dc.date.available2022-03-23T11:41:28Z
dc.date.issued2022
dc.description.abstractStem cell destiny can be controlled with scaffold biomaterials in tissue engineering and regenerative medicine. This study aimed to investigate the neuronal differentiation potential of human adipose tissue-derived mesenchymal stem cells in graphene nanofiber matrix in vitro. Stem cell isolation was performed from adipose tissue taken from human by mechanical and enzymatic methods. The differentiation potential was examined after incubation of adipose stem cells in normal medium and neural differentiation medium, on graphene oxide (GO) and polycaprolactone (PCL) composite scaffolds produced by electrospinning technique. In vitro studies indicated that the presence of GO in PCL scaffold increases an effect on cell attachment, proliferation, infiltration into the scaffold, and neuronal differentiation. Also, unlike subcutaneous tissue, it has been shown immunohistochemically that mesenchymal stem cells derived from epidural adipose tissue tend to differentiate into oligodendrocytes. © 2022 Elsevier Ltd
dc.identifier.doi10.1016/j.eurpolymj.2022.111000
dc.identifier.issn143057
dc.identifier.urihttps://hdl.handle.net/11424/254658
dc.language.isoeng
dc.publisherElsevier Ltd
dc.relation.ispartofEuropean Polymer Journal
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAdipose-derived stem cell
dc.subjectElectrospinning
dc.subjectGraphene oxide
dc.subjectNanofiber scaffold
dc.subjectNeuronal differentiation
dc.subjectPolycaprolactone
dc.titleThe effect of polycaprolactone/graphene oxide electrospun scaffolds on the neurogenic behavior of adipose stem cells
dc.typearticle
dspace.entity.typePublication
local.avesis.id88a130bd-580c-457a-9853-f56894729957
local.import.packageSS28
local.import.sourceScopus
local.indexed.atSCOPUS
local.journal.articlenumber111000
oaire.citation.titleEuropean Polymer Journal
oaire.citation.volume165
relation.isAuthorOfPublicationdda71138-8ce4-4265-89b2-73bc94786a4f
relation.isAuthorOfPublication.latestForDiscoverydda71138-8ce4-4265-89b2-73bc94786a4f

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