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Effects of ACE inhibition and Angiotensin II receptor blockade on glomerular basement membrane protein excretion and charge selectivity in Type 2 diabetic patients

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dc.contributor.authorVELİOĞLU ÖĞÜNÇ, AYLİZ
dc.contributor.authorsDeyneli, Oguzhan; Yavuz, Dilek; Velioglu, Ayliz; Cacina, Hasan; Aksoy, Nihal; Haklar, Goncaguel; Taga, Yavuz; Akalin, Sema
dc.date.accessioned2022-03-14T08:18:57Z
dc.date.available2022-03-14T08:18:57Z
dc.date.issued2006-06
dc.description.abstractAngiotensin-converting enzyme (ACE) inhibitors may reduce urinary albumin excretion (UAE) by decreasing glomerular pressure and increasing glomerular charge selectivity through preservation of glycosaminoglycans. The effect of Angiotensin II antagonism on glomerular charge selectivity remains to be determined. The aim of this study was to compare the effects of an AT, blocker losartan and an ACE inhibitor (ACE-I) enalapril on UAE, extracellular matrix proteins, glycosaminoglycan excretion(U-GAG) and red blood cell anionic charge (RBCCh) which are the indirect markers of glomerular basement membrane anionic content in hypertensive Type 2 diabetic patients. Twenty-four patients were randomised into two groups and received either enalapril (5-20 mg/d) or losartan (50-100 mg/d). All parameters were measured at baseline and after six months of treatment. At the end of six months, systolic and diastolic blood pressures (BP), UAE rates, U-GAG excretion and RBCCh were significantly and equally reduced in both treatment groups compared with baseline. RBCCh was negatively correlated with UAE (r = -0.57, p < 0.0001) and U-GAG excretion (r = -0.57, p < 0.0001); UAE was correlated with U-GAG excretion (r = 0.58, p < 0.0001). In conclusion, enalapril and losartan treatment were equally effective in reducing BP, UAE as well as U-GAG excretion and preserving RBCCh in hypertensive Type 2 diabetic patients. ACE inhibition and AT(1)-receptor blockade may have favourable effects on preserving glomerular anionic content in hypertensive diabetic patients.
dc.identifier.doi10.3317/jraas.2006.016
dc.identifier.issn1470-3203
dc.identifier.pubmed17083064
dc.identifier.urihttps://hdl.handle.net/11424/241514
dc.identifier.wosWOS:000240412900006
dc.language.isoeng
dc.publisherJ R A A S LTD
dc.relation.ispartofJOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjecthypertension
dc.subjectType 2 diabetes mellitus
dc.subjectglomerular charge selectivity
dc.subjectangiotensin-converting enzyme inhibitors
dc.subjectAngiotensin II receptor blockers
dc.subjectCONVERTING-ENZYME-INHIBITION
dc.subjectHEPARAN-SULFATE PROTEOGLYCAN
dc.subjectSIZE-SELECTIVITY
dc.subjectURINARY GLYCOSAMINOGLYCAN
dc.subjectEXTRACELLULAR-MATRIX
dc.subjectIV COLLAGEN
dc.subjectNEPHROPATHY
dc.subjectMELLITUS
dc.subjectMICROALBUMINURIA
dc.subjectLOSARTAN
dc.titleEffects of ACE inhibition and Angiotensin II receptor blockade on glomerular basement membrane protein excretion and charge selectivity in Type 2 diabetic patients
dc.typearticle
dspace.entity.typePublication
local.avesis.id14028834-4a71-4536-8c3e-f23104ea6f2f
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages6
oaire.citation.endPage103
oaire.citation.issue2
oaire.citation.startPage98
oaire.citation.titleJOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
oaire.citation.volume7
relation.isAuthorOfPublication13300bf6-ba96-4f87-9868-b0d2c86f572a
relation.isAuthorOfPublication.latestForDiscovery13300bf6-ba96-4f87-9868-b0d2c86f572a

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