Publication:
Flavonoids and antioxidant activity of Rosa agrestis leaves

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dc.contributor.authorBİTİŞ, LEYLA
dc.contributor.authorsBitis, Leyla; Kultur, Sukran; Melikoglu, Gulay; Ozsoy, Nurten; Can, Ayse
dc.date.accessioned2022-03-12T17:47:55Z
dc.date.available2022-03-12T17:47:55Z
dc.date.issued2010
dc.description.abstractIn this work we report the isolation and characterisation of seven flavonoids, the levels of total phenolics, flavonoids and proanthocyanidins, and the antioxidant activity of the leaf extract of Rosa agrestis Savi (Rosaceae). The results showed that the R. agrestis leaf extract exhibited significant antioxidative activity as measured by 2,2-diphenyl-1-picrylhydrazyl (DPPH) (EC50 = 47.4 mu g mL-1), inhibited both -carotene bleaching and deoxyribose degradation, quenched a chemically generated superoxide anion in vitro and showed high ferrous ion chelating activity. Reactivity towards 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt (ABTS) radical cation and ferric-reducing antioxidant power (FRAP) values were equivalent to 2.30 mM L-1 Trolox, the water soluble -tocopherol analogue, and 1.91 mM L-1 Fe2+, respectively. The high antioxidant activity of the extract appeared to be attributed to its high content of total phenolics, flavonoids and proanthocyanidins. The flavonoids isolated from R. agrestis leaves were diosmetin, kaempherol, quercetin, kaempherol 3-glucoside (astragalin), quercetin 3-rhamnoside (quercitrin), quercetin 3-xyloside and quercetin 3-galactoside (hyperoside). Diosmetin (5,7,3'-trihydroxy-4'-methoxyflavone) was isolated for the first time from Rosa species.
dc.identifier.doi10.1080/14786410903075507
dc.identifier.eissn1478-6427
dc.identifier.issn1478-6419
dc.identifier.pubmed20397108
dc.identifier.urihttps://hdl.handle.net/11424/229863
dc.identifier.wosWOS:000277661000012
dc.language.isoeng
dc.publisherTAYLOR & FRANCIS LTD
dc.relation.ispartofNATURAL PRODUCT RESEARCH
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectantioxidant activity
dc.subjectflavonoids
dc.subjectpolyphenol content
dc.subjectRosa agrestis
dc.subjectEXTRACTS
dc.subjectPOLYPHENOLS
dc.subjectL.
dc.titleFlavonoids and antioxidant activity of Rosa agrestis leaves
dc.typearticle
dspace.entity.typePublication
local.avesis.ide4ba57f4-8e41-4fca-951b-46d22602a2ca
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.articlenumberPII 921273596
local.journal.numberofpages10
oaire.citation.endPage589
oaire.citation.issue6
oaire.citation.startPage580
oaire.citation.titleNATURAL PRODUCT RESEARCH
oaire.citation.volume24
relation.isAuthorOfPublication9f91deeb-ccc1-4ec8-adaa-eb62ad76b556
relation.isAuthorOfPublication.latestForDiscovery9f91deeb-ccc1-4ec8-adaa-eb62ad76b556

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