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In vitro investigation of antimicrobial, enzyme inhibitory and free radical scavenging activities of Inula salicina L.

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dc.contributor.authorYILDIRIM, AYBENİZ
dc.contributor.authorŞEN, ALİ
dc.contributor.authorŞENKARDEŞ, İSMAİL
dc.contributor.authorBİTİŞ, LEYLA
dc.contributor.authorsYıldırım A., ŞEN A., HACIOĞLU M., BİRTEKSÖZ TAN A. S. , ŞENKARDEŞ İ., BİTİŞ L.
dc.date.accessioned2022-11-18T17:57:56Z
dc.date.available2022-11-18T17:57:56Z
dc.date.issued2022-09-01
dc.description.abstractIn this study, in vitro biological activities and total phenol/flavonoid contents of methanol extract (ISM) and its hexane (ISH), chloroform (ISC), ethyl acetate (ISEA) and aqueous methanol (ISAM) fractions obtained from aerial parts of Inula salicina were investigated. ISEA showed the highest antioxidant activity against DPPH and ABTS radicals with an IC50 value of 0.014 mg ml-1 for both assays. ISEA exhibited a good anti-inflammatory activity with an IC50 value of 0.060 mg ml-1 . ISEA was found to exhibit a moderate level of antidiabetic activity against α amylase enzyme with an IC50 value of 0.290 mg ml-1 . ISEA and ISM presented low and moderate inhibitory activity against acetylcholinesterase and butyrylcholinesterase enzymes with IC50 values of 0.577 and 0.279 mg ml-1 , respectively. ISC with MIC values of 78 and 156 µg ml-1 displayed a significant antimicrobial activity against Staphylococcus aureus and S. epidermidis, respectively. Almost all extracts had moderate effect against Candida species. The highest total phenolic and flavonoid contents were determined in ISEA with 574.8 mg GAE (gallic acid equivalent) g -1 extract and 30.48 mg QE (quercetin equivalent) g -1 extract, respectively. These results showed that ISEA had a good antioxidant and anti-inflammatory activity with moderate α-amylase and butyrylcholinesterase inhibitory activity. Also, ISC exhibited a significant antimicrobial activity against Staphylococcus species.
dc.identifier.citationYıldırım A., ŞEN A., HACIOĞLU M., BİRTEKSÖZ TAN A. S. , ŞENKARDEŞ İ., BİTİŞ L., "In vitro investigation of antimicrobial, enzyme inhibitory and free radical scavenging activities of Inula salicina L.", International Journal of Agriculture, Environment and Food Sciences, cilt.6, sa.3, ss.389-395, 2022
dc.identifier.doi10.31015/jaefs.2022.3.7
dc.identifier.endpage395
dc.identifier.issn2602-246X
dc.identifier.issue3
dc.identifier.startpage389
dc.identifier.urihttp://dx.doi.org/10.31015/jaefs.2022.3.7
dc.identifier.urihttps://hdl.handle.net/11424/283230
dc.identifier.volume6
dc.language.isoeng
dc.relation.ispartofInternational Journal of Agriculture, Environment and Food Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTarımsal Bilimler
dc.subjectSağlık Bilimleri
dc.subjectAgricultural Sciences
dc.subjectHealth Sciences
dc.subjectTarım ve Çevre Bilimleri (AGE)
dc.subjectKlinik Tıp (MED)
dc.subjectAgriculture & Environment Sciences (AGE)
dc.subjectClinical Medicine (MED)
dc.subjectAsteraceae
dc.subjectBiological activity
dc.subjectExtracts
dc.subjectFractions
dc.subjectInula salicina
dc.titleIn vitro investigation of antimicrobial, enzyme inhibitory and free radical scavenging activities of Inula salicina L.
dc.typearticle
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery1c189866-472e-4ed7-ab13-42bdcd866289

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