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EFFECT OF METHYLENE-BLUE ON BLOOD-PRESSURE IN RATS

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dc.contributor.authorONAT, FİLİZ
dc.contributor.authorsOKTAY, S; ONAT, F; KARAHAN, F; ALICAN, I; OZKUTLU, U; YEGEN, BC
dc.date.accessioned2022-03-12T16:56:13Z
dc.date.available2022-03-12T16:56:13Z
dc.date.issued1993
dc.description.abstractMethylene blue (MB) is a soluble guanylate cyclase inhibitor, and known as an endothelium-derived relaxing factor (EDRF) inhibitor in vitro. In the present study, it was demonstrated that intravenous administration of MB caused a dose-dependent hypertensive effect in rats. The hypertensive responses to the higher doses (10 and 20 mg/kg) of MB was followed by a reflex hypotension which did not appear in pithed rats. Noradrenaline depletion by reserpine pretreatment did not inhibit MB-induced hypertension, but abolished the hypotensive response. Both hypertensive and hypotensive phases were not altered by indometacin. These results may suggest that in vivo guanylate cyclase inhibition leads to an increase in blood pressure; prostaglandins and noradrenaline release from sympathetic nerve endings do not contribute to MB-induced hypertension and it may be due in part to the inhibition of EDRF.
dc.identifier.doi10.1159/000139047
dc.identifier.issn0031-7012
dc.identifier.pubmed8483967
dc.identifier.urihttps://hdl.handle.net/11424/226699
dc.identifier.wosWOS:A1993KT76400004
dc.language.isoeng
dc.publisherKARGER
dc.relation.ispartofPHARMACOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectMETHYLENE BLUE
dc.subjectBLOOD PRESSURE
dc.subjectVASCULAR SMOOTH-MUSCLE
dc.subjectNITRIC-OXIDE
dc.subjectCYCLIC-GMP
dc.subjectINDUCED RELAXATION
dc.subjectENDOTHELIAL-CELLS
dc.subjectRELAXING FACTOR
dc.subjectRABBIT AORTA
dc.subjectACETYLCHOLINE
dc.subjectNITROGLYCERIN
dc.subjectGENERATION
dc.titleEFFECT OF METHYLENE-BLUE ON BLOOD-PRESSURE IN RATS
dc.typearticle
dspace.entity.typePublication
local.avesis.id664a8f32-4769-43de-b79d-c6d4f07e23c0
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages5
oaire.citation.endPage210
oaire.citation.issue4
oaire.citation.startPage206
oaire.citation.titlePHARMACOLOGY
oaire.citation.volume46
relation.isAuthorOfPublicationc359dea3-046f-4397-90d5-62e4bfc31869
relation.isAuthorOfPublication.latestForDiscoveryc359dea3-046f-4397-90d5-62e4bfc31869

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