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Recent Advances in Apoptosis: The Role of Hydrazones

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dc.contributor.authorSÜZGÜN, PELİN
dc.contributor.authorsCikla-Suzgun, Pelin; Kucukguzel, S. Guniz
dc.date.accessioned2022-03-10T15:25:30Z
dc.date.available2022-03-10T15:25:30Z
dc.date.issued2019
dc.description.abstractThe process of programmed cell death in higher eukaryotes (apoptosis), is generally characterized by distinct morphological characteristics and energy-dependent biochemical mechanisms. Apoptosis is considered as a vital component of various processes including normal cell turnover, proper development and functioning of the immune system, hormone-dependent atrophy, embryonic development and chemical-induced cell death. Apoptosis seems to play an important key role in the progression of several human diseases like Alzheimer's disease, Parkinson's disease and many types of cancer. Promotion of apoptosis may be a good approach for the prevention of cancer cell proliferation. In early studies, antitumor compounds have been found to induce the apoptotic process in tumor cells. On the other hand, several hydrazones were reported to have lower toxicity than hydrazides due to the blockage of -NH2 group. Therefore, the design of hydrazones that activate and promote apoptosis is an attractive strategy for the discovery and development of potential anticancer agents. The aim of this review is to provide a general overview of current knowledge and the connection between apoptosis and hydrazone. It is also the guide for the apoptotic activities of new hydrazone derivatives.
dc.identifier.doi10.2174/1389557519666190410125910
dc.identifier.eissn1875-5607
dc.identifier.issn1389-5575
dc.identifier.pubmed30968776
dc.identifier.urihttps://hdl.handle.net/11424/220269
dc.identifier.wosWOS:000495010200003
dc.language.isoeng
dc.publisherBENTHAM SCIENCE PUBL LTD
dc.relation.ispartofMINI-REVIEWS IN MEDICINAL CHEMISTRY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectApoptosis
dc.subjecthydrazone
dc.subjectcancer
dc.subjectcaspase-8
dc.subjectcaspase-3
dc.subjectBcl-2
dc.subjectCELL-CYCLE
dc.subjectBIOLOGICAL EVALUATION
dc.subjectHYDRAZIDE-HYDRAZONE
dc.subjectANTITUMOR ACTIVITIES
dc.subjectCYTOTOXIC ACTIVITY
dc.subjectMOLECULAR DOCKING
dc.subjectPRO-APOPTOSIS
dc.subjectCANCER
dc.subjectDERIVATIVES
dc.subjectDISCOVERY
dc.titleRecent Advances in Apoptosis: The Role of Hydrazones
dc.typereview
dspace.entity.typePublication
local.avesis.id3a1d1386-fefb-4123-a1c3-d29ad838d30e
local.import.packageSS5
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages16
local.journal.quartileQ3
oaire.citation.endPage1442
oaire.citation.issue17
oaire.citation.startPage1427
oaire.citation.titleMINI-REVIEWS IN MEDICINAL CHEMISTRY
oaire.citation.volume19
relation.isAuthorOfPublication6f8a150f-0ec8-4a51-9a1b-b9c26aecdf69
relation.isAuthorOfPublication.latestForDiscovery6f8a150f-0ec8-4a51-9a1b-b9c26aecdf69

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