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Synthesis and anticancer activity of novel hydrazone linkage-based aryl sulfonate derivatives as apoptosis inducers

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dc.contributor.authorBİNGÖL ÖZAKPINAR, ÖZLEM
dc.contributor.authorsSenkardes, Sevil; Han, M. Ihsan; Gurboga, Merve; Ozakpinar, Ozlem Bingol; Kucukguzel, S. Guniz
dc.date.accessioned2022-03-23T14:08:59Z
dc.date.available2022-03-23T14:08:59Z
dc.date.issued2022-02
dc.description.abstractIn the present study, the various 28 hybrid molecules containing hydrazone and sulfonate moieties were synthesized and characterized by FTIR, H-1-NMR, C-13-NMR spectroscopy and LC-MS spectrometry, besides elemental analysis. The compounds were evaluated for their antiproliferative effects against six cancer cell lines, namely A549 (non-small cell lung cancer), MCF-7 (breast cancer), HT-29 (colorectal adenocarcinoma cancer), PC-3 (androgen-independent prostate adenocarcinoma), Hep3B (hepatocellular carcinoma cancer), and HeLa (epitheloid cervix carcinoma cancer). Among all the target compounds, compounds 4g and 4h exhibited more promising effects on MCF-7 cell lines (IC50 = 17.8 mu M and 21.2 mu M, respectively) with high selectivity. Further mechanistic studies proposed that compounds 4g and 4h induced apoptosis is mediated through the intrinsic apoptotic pathway with changes in mitochondrial membrane potential by finally activating caspase-9 and caspase-3. The results have been encouraging enough to merit further investigation. [GRAPHICS] .
dc.identifier.doi10.1007/s00044-021-02837-z
dc.identifier.eissn1554-8120
dc.identifier.issn1054-2523
dc.identifier.urihttps://hdl.handle.net/11424/254714
dc.identifier.wosWOS:000741919500001
dc.language.isoeng
dc.publisherSPRINGER BIRKHAUSER
dc.relation.ispartofMEDICINAL CHEMISTRY RESEARCH
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHydrazone
dc.subjectSulfonate
dc.subjectAnticancer activity
dc.subjectApoptosis
dc.subjectCaspase activity
dc.subjectBIOLOGICAL-ACTIVITIES
dc.subjectDYSFUNCTION
dc.subjectNS5B
dc.titleSynthesis and anticancer activity of novel hydrazone linkage-based aryl sulfonate derivatives as apoptosis inducers
dc.typearticle
dspace.entity.typePublication
local.avesis.id3ac0251e-910d-4bce-a400-4f27305cea90
local.import.packageSS27
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages12
oaire.citation.endPage379
oaire.citation.issue2
oaire.citation.startPage368
oaire.citation.titleMEDICINAL CHEMISTRY RESEARCH
oaire.citation.volume31
relation.isAuthorOfPublication44b61e5d-4045-4d63-926e-2f01c3ee5642
relation.isAuthorOfPublication.latestForDiscovery44b61e5d-4045-4d63-926e-2f01c3ee5642

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