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Fabrication and optimization of 3D printed gelatin methacryloyl microneedle arrays based on vat photopolymerization

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dc.contributor.authorGÜNDÜZ, OĞUZHAN
dc.contributor.authorsBaykara D., Bedir T., Ilhan E., Mutlu M. E., GÜNDÜZ O., Narayan R., ÜSTÜNDAĞ C. B.
dc.date.accessioned2023-06-05T11:03:33Z
dc.date.available2023-06-05T11:03:33Z
dc.date.issued2023-01-01
dc.description.abstractMicroneedles (MNs) are micrometer-sized arrays that can penetrate the skin in a minimally invasive manner; these devices offer tremendous potential for the transdermal delivery of therapeutic molecules. Although there are many conventional techniques for manufacturing MNs, most of them are complicated and can only fabricate MNs with specific geometries, which restricts the ability to adjust the performance of the MNs. Herein, we present the fabrication of gelatin methacryloyl (GelMA) MN arrays using the vat photopolymerization 3D printing technique. This technique allows for the fabrication of high-resolution and smooth surface MNs with desired geometries. The existence of methacryloyl groups bonded to the GelMA was verified by 1H NMR and FTIR analysis. To examine the effects of varying needle heights (1000, 750, and 500 µm) and exposure times (30, 50, and 70 s) on GelMA MNs, the height, tip radius, and angle of the needles were measured; their morphological and mechanical properties were also characterized. It was observed that as the exposure time increased, the height of the MNs increased; moreover, sharper tips were obtained and tip angles decreased. In addition, GelMA MNs exhibited good mechanical performance with no breakage up to 0.3 mm displacement. These results indicate that 3D printed GelMA MNs have great potential for transdermal delivery of various therapeutics.
dc.identifier.citationBaykara D., Bedir T., Ilhan E., Mutlu M. E., GÜNDÜZ O., Narayan R., ÜSTÜNDAĞ C. B., "Fabrication and optimization of 3D printed gelatin methacryloyl microneedle arrays based on vat photopolymerization", Frontiers in Bioengineering and Biotechnology, cilt.11, 2023
dc.identifier.doi10.3389/fbioe.2023.1157541
dc.identifier.issn2296-4185
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85160205501&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/289920
dc.identifier.volume11
dc.language.isoeng
dc.relation.ispartofFrontiers in Bioengineering and Biotechnology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectCerrahi Tıp Bilimleri
dc.subjectPatoloji
dc.subjectBiyomedikal Mühendisliği
dc.subjectYaşam Bilimleri
dc.subjectBiyoteknoloji
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectBiyokimya
dc.subjectTemel Bilimler
dc.subjectMühendislik ve Teknoloji
dc.subjectMedicine
dc.subjectSurgery Medicine Sciences
dc.subjectPathology
dc.subjectBiomedical Engineering
dc.subjectLife Sciences
dc.subjectBiotechnology
dc.subjectHealth Sciences
dc.subjectFundamental Medical Sciences
dc.subjectBiochemistry
dc.subjectNatural Sciences
dc.subjectEngineering and Technology
dc.subjectMühendislik, Bilişim ve Teknoloji (ENG)
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMühendislik
dc.subjectBiyoloji ve Biyokimya
dc.subjectMikrobiyoloji
dc.subjectPATOLOJİ
dc.subjectBİYOTEKNOLOJİ VE UYGULAMALI MİKROBİYOLOJİ
dc.subjectMÜHENDİSLİK, BİYOMEDİKAL
dc.subjectEngineering, Computing & Technology (ENG)
dc.subjectLife Sciences (LIFE)
dc.subjectENGINEERING
dc.subjectBIOLOGY & BIOCHEMISTRY
dc.subjectMICROBIOLOGY
dc.subjectPATHOLOGY
dc.subjectBIOTECHNOLOGY & APPLIED MICROBIOLOGY
dc.subjectENGINEERING, BIOMEDICAL
dc.subjectBiyomühendislik
dc.subjectFizik Bilimleri
dc.subjectHistoloji
dc.subjectBiyomedikal mühendisliği
dc.subjectBioengineering
dc.subjectPhysical Sciences
dc.subjectHistology
dc.subject3D printing
dc.subjectgelatin methacryloyl
dc.subjecthydrogel
dc.subjectmicroneedle
dc.subjectvat photopolymerization and additive manufacturing
dc.subjectgelatin methacryloyl
dc.subjecthydrogel
dc.subjectmicroneedle
dc.subjectvat photopolymerization and additive manufacturing
dc.subject3D printing
dc.titleFabrication and optimization of 3D printed gelatin methacryloyl microneedle arrays based on vat photopolymerization
dc.typearticle
dspace.entity.typePublication
local.avesis.id1046b867-3ae7-4a40-916c-893748423509
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublicationf11e8073-bf2f-485f-9bdf-5b3a2a0bdc1f
relation.isAuthorOfPublication.latestForDiscoveryf11e8073-bf2f-485f-9bdf-5b3a2a0bdc1f

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