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Investigation of HMG-CoA reductase inhibitory and antioxidant effects of various hydroxycoumarin derivatives

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dc.contributor.authorOGAN, AYŞE
dc.contributor.authorsOzalp, Lalehan; Danis, Ozkan; Yuce-Dursun, Basak; Demir, Serap; Gunduz, Cihan; Ogan, Ayse
dc.date.accessioned2022-03-12T22:42:12Z
dc.date.available2022-03-12T22:42:12Z
dc.date.issued2020
dc.description.abstractCardiovascular diseases are one of the primary causes of deaths worldwide, and the development of atherosclerosis is closely related to hypercholesterolemia. As the reduction of the low-density lipoprotein cholesterol level is critical for treating these diseases, the inhibition of 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase, which is essentially responsible for cholesterol biosynthesis, stands out as a key solution to lower plasma cholesterol levels. In this study, we synthesized several dihydroxycoumarins and investigated their antioxidant and in vitro HMG-CoA reductase inhibitory effects. Furthermore, we carried out in silico studies and examined the quantum-chemical properties of the coumarin derivatives. We also performed molecular docking experiments and analyzed the binding strength of each coumarin derivative. Our results revealed that compoundIVdisplayed the highest HMG-CoA reductase inhibitory activity (IC50 = 42.0 mu M) in vitro. Cupric-reducing antioxidant capacity and ferric-reducing antioxidant power assays demonstrated that coumarin derivatives exhibit potent antioxidant activities. Additionally, a close relationship was found between the lowest unoccupied molecular orbital energy levels and the antioxidant activities.
dc.identifier.doi10.1002/ardp.201900378
dc.identifier.eissn1521-4184
dc.identifier.issn0365-6233
dc.identifier.pubmed32648617
dc.identifier.urihttps://hdl.handle.net/11424/236212
dc.identifier.wosWOS:000546672400001
dc.language.isoeng
dc.publisherWILEY-V C H VERLAG GMBH
dc.relation.ispartofARCHIV DER PHARMAZIE
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectantioxidant
dc.subjectcoumarin
dc.subjectHMG-CoA reductase
dc.subjectlipid lowering
dc.subjectradical scavenging
dc.subjectMECHANISM
dc.subjectCOUMARIN
dc.subjectDOCKING
dc.subjectETHERS
dc.titleInvestigation of HMG-CoA reductase inhibitory and antioxidant effects of various hydroxycoumarin derivatives
dc.typearticle
dspace.entity.typePublication
local.avesis.idf1b9edfd-5a76-42ea-b6cf-e52deaeba577
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.articlenumbere1900378
local.journal.numberofpages9
local.journal.quartileQ2
oaire.citation.issue10
oaire.citation.titleARCHIV DER PHARMAZIE
oaire.citation.volume353
relation.isAuthorOfPublication58db3332-a5f8-4224-a021-aeea795f52fa
relation.isAuthorOfPublication.latestForDiscovery58db3332-a5f8-4224-a021-aeea795f52fa

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