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Electronic home monitoring of children with cystic fibrosis to detect and treat acute pulmonary exacerbations and its effect on 1-year FEV1

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dc.contributor.authorUZMANOĞLU, MUSTAFA SELÇUK
dc.contributor.authorERGENEKON, ALMALA PINAR
dc.contributor.authorGÖKDEMİR, YASEMİN
dc.contributor.authorERDEM ERALP, ELA
dc.contributor.authorsYanaz M., Yilmaz Yegit C., Gulieva A., Kalyoncu M., UZMANOĞLU M. S., Uzunoglu B., Tastan G., ERGENEKON A. P., GÖKDEMİR Y., ERDEM ERALP E., et al.
dc.date.accessioned2023-12-11T08:45:18Z
dc.date.available2023-12-11T08:45:18Z
dc.date.issued2023-01-01
dc.description.abstractBackground: We aimed to investigate the effect of the use of electronic home spirometry in children with cystic fibrosis (CF) on 1-year FEV1 (% predicted, pp) change. Methods: This is a randomised, one-year prospective study including children with CF between 6 and 18 years of age. Subjects were randomised into home spirometry group (HSG) and usual care group (UCG). Children in HSG performed two pulmonary function tests (PFT) per week. Data regarding acute pulmonary exacerbations (PEx) was obtained from patients’ records. At baseline and 12th month, health related quality of life questionnaire for CF patients (CFQ-R) and lung clearance index (LCI) were performed. Results: Sixty children were recruited with a median (IQR) age of 13.3 (11.4–15.4) years. Absolute change in FEV1pp from baseline to 12th month as median (IQR) was +1% (-6.75–9.75) in HSG and -2.50% (-7.50–3.25) in UCG (p = 0.10). Sensitivity analysis including only adherent children in HSG (n = 22), yielded an increase of 5% (-3.50–12) in HSG and a decrease of 2.50% (-7.50–3.25) in UCG (p = 0.009). A total of 29 (96.7%) subjects in HSG and 23 (76.7%) in UCG had PEx (p = 0.05). Absolute change in median (IQR) LCI2.5 from baseline to the 12th month was -1.6 [-2.9–0] (p<0.001) in HSG and -1.5 [-2.8-(-0.6)] (p<0.001) in UCG (p = 0.94). There was a significant increase in the social domain of the CFQ-R in HSG (from 59.1 to 76.2, p = 0.01). Conclusions: Electronic home monitoring of children with CF by spirometry may result in improvement in lung function.
dc.identifier.citationYanaz M., Yilmaz Yegit C., Gulieva A., Kalyoncu M., UZMANOĞLU M. S., Uzunoglu B., Tastan G., ERGENEKON A. P., GÖKDEMİR Y., ERDEM ERALP E., et al., "Electronic home monitoring of children with cystic fibrosis to detect and treat acute pulmonary exacerbations and its effect on 1-year FEV1", Journal of Cystic Fibrosis, 2023
dc.identifier.doi10.1016/j.jcf.2023.09.007
dc.identifier.issn1569-1993
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85171891259&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/295530
dc.language.isoeng
dc.relation.ispartofJournal of Cystic Fibrosis
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectÇocuk Sağlığı ve Hastalıkları
dc.subjectGöğüs Hastalıkları ve Allerji
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectInternal Medicine Sciences
dc.subjectChild Health and Diseases
dc.subjectChest Diseases and Allergy
dc.subjectHealth Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectSOLUNUM SİSTEMİ
dc.subjectPEDİATRİ
dc.subjectClinical Medicine (MED)
dc.subjectCLINICAL MEDICINE
dc.subjectRESPIRATORY SYSTEM
dc.subjectPEDIATRICS
dc.subjectPediatri, Perinatoloji ve Çocuk Sağlığı
dc.subjectAkciğer ve Solunum Tıbbı
dc.subjectPediatrics, Perinatology and Child Health
dc.subjectPulmonary and Respiratory Medicine
dc.subjectCystic fibrosis
dc.subjectForced expiratory volume in 1 second
dc.subjectHome spirometry
dc.subjectPulmonary exacerbations
dc.titleElectronic home monitoring of children with cystic fibrosis to detect and treat acute pulmonary exacerbations and its effect on 1-year FEV1
dc.typearticle
dspace.entity.typePublication
local.avesis.id9144fc22-d2cc-4fcc-b941-5b76456662d4
local.indexed.atPUBMED
local.indexed.atSCOPUS
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relation.isAuthorOfPublication.latestForDiscovery0747a69a-c7e0-4809-a101-0a268e3629e9

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