Publication:
Inflammatory response to cold injury in remote organs is reduced by corticotropin-releasing factor

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dc.contributor.authorYEGEN, BERRAK
dc.contributor.authorsBozkurt, A.; Ghandour, S.; Okboy, N.; Oner, S.; Arbak, S.; Coşkun, T.; Yeğen, B. C.
dc.date.accessioned2022-03-15T11:10:58Z
dc.date.available2022-03-15T11:10:58Z
dc.date.issued2001
dc.description.abstractCurrent experimental evidence concerning the potential activity of corticotropin releasing factor (CRF) in inflammatory processes still remains controversial. To determine whether CRF has protective effects on three remote organs (liver, lung and stomach) affected by cold injury and to characterize the role of neutrophils in cold-induced inflammation, dorsums of anesthetized rats were exposed for 5 min to a 22% NaCl solution maintained at -20+/-0.5 degrees C and the rats were sacrificed at 24 h after the cold injury. The results indicate that cold-exposure-induced edema in the liver, lung and stomach was blocked by subcutaneous (s.c.; 1.2 and 12 nmol/kg; 30 min before cold trauma) CRF pretreatment, while the central administration of CRF (intracisternally (i.c.); 0.30 and 1.5 nmol/rat; 15 min before cold) had the similar effect at the higher dose. Histological assessment and the tissue myeloperoxidase activities also revealed that CRF given peripherally has a protective role in damage generation. Moreover, CRF had a facilitatory effect in the recovery of the body temperature following cold exposure. In conclusion, CRF is likely to act on its peripheral receptors in the inflamed remote organs, suppressing the edematogenic effects of inflammatory mediators, some of which are neutrophil-derived.
dc.identifier.doi10.1016/s0167-0115(01)00239-7
dc.identifier.issn0167-0115
dc.identifier.pubmedPMID: 11384774
dc.identifier.urihttps://hdl.handle.net/11424/248821
dc.language.isoeng
dc.relation.ispartofRegulatory Peptides
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectFemale
dc.subjectAnimals
dc.subjectMale
dc.subjectRats
dc.subjectLiver
dc.subjectPeroxidase
dc.subjectInflammation
dc.subjectInjections, Subcutaneous
dc.subjectLung
dc.subjectAnti-Inflammatory Agents
dc.subjectCorticotropin-Releasing Hormone
dc.subjectStomach
dc.subjectBody Temperature
dc.subjectFreezing
dc.subjectOrgan Size
dc.titleInflammatory response to cold injury in remote organs is reduced by corticotropin-releasing factor
dc.typearticle
dspace.entity.typePublication
local.avesis.ida0e47bb9-d8e8-416a-8766-0a5ec6d8a26d
local.import.packageSS23
local.import.sourcePubMed
local.indexed.atPUBMED
oaire.citation.endPage139
oaire.citation.startPage131
oaire.citation.titleRegulatory Peptides
oaire.citation.volume2-3
relation.isAuthorOfPublicatione4eaf9ac-f8dc-4e2b-b940-895cc906790d
relation.isAuthorOfPublication.latestForDiscoverye4eaf9ac-f8dc-4e2b-b940-895cc906790d

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