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In vitro anti-urease, antioxidant, anticholinesterase, cytotoxic and in vivo anti-inflammatory potential of Satureja cuneifolia Ten.

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dc.contributor.authorŞENKARDEŞ, İSMAİL
dc.contributor.authorsTaskin, Turgut; Dogan, Murat; Cam, Muhammet E.; Sahin, Talip; Senkardes, Ismail
dc.date.accessioned2022-03-02T05:42:10Z
dc.date.available2022-03-02T05:42:10Z
dc.date.issued2020-06-29
dc.description.abstractSatureja cuneifolia Ten. (wild savoury) belongs to the Lamiaceae family and is used to produce essential oil and aromatic water. This plant is also used as a condiment and herbal tea due to its stimulating, tonic and carminative effects. The in vitro antioxidant, anti-urease, anticholinesterase and cytotoxic activities of the different extracts from the plant’s aerial parts were examined. Besides, the in vivo anti-inflammatory activities of the fraction and direct methanol extracts were determined comparatively. In the current study, fraction methanol extract exhibited the strongest ABTS (52.34 mM trolox/mg extract) radical scavenging and ferric reduction (17.22 mM Fe2+/mg extract) activity. It was also found that the fraction methanol extract had stronger anti-urease (12.52%) and anticholinesterase (69.02%) activity than other extracts.  The XTT results showed that fraction methanol extract had the most cytotoxic activity on MCF-7 cell lines (39.92%).  According to the results of in vivo anti-inflammatory activity, it was found that both fraction and direct methanol extracts exhibited close and significant anti-inflammatory activity. The fact that methanol extracts have significant biological activity suggests that these may be used as a natural source in the future.
dc.identifier.doi10.15835/nsb12210687
dc.identifier.issn2067-3264, 2067-3205
dc.identifier.issue2
dc.identifier.pages222-232
dc.identifier.urihttps://hdl.handle.net/11424/218702
dc.identifier.volume12
dc.language.isoeng
dc.relation.urihttps://www.notulaebiologicae.ro/index.php/nsb/article/view/10687
dc.titleIn vitro anti-urease, antioxidant, anticholinesterase, cytotoxic and in vivo anti-inflammatory potential of Satureja cuneifolia Ten.
dc.typearticle
dspace.entity.typePublication
local.avesis.idb411c82b-ff6e-40c5-b73f-bd7d0d735be6
relation.isAuthorOfPublication3e59035c-d7b1-4887-b78c-2a9bc207de05
relation.isAuthorOfPublication.latestForDiscovery3e59035c-d7b1-4887-b78c-2a9bc207de05

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