Publication:
Outcome of solid and cavitary pulmonary nodules in rheumatoid arthritis patients— case series

Simple item page
dc.contributor.authorAKSOY, AYSUN
dc.contributor.authorBOZKURTLAR, EMİNE
dc.contributor.authorKARAKURT, SAİT
dc.contributor.authorERYÜKSEL, SEMİHA EMEL
dc.contributor.authorİNANÇ, GÜZİDE NEVSUN
dc.contributor.authorKOCAKAYA, DERYA
dc.contributor.authorsAKSOY A., KOCAKAYA D., Yalçinkaya Y., BOZKURTLAR E., KARAKURT S., Eryüksel E., İnanç N.
dc.date.accessioned2022-12-22T12:35:41Z
dc.date.available2022-12-22T12:35:41Z
dc.date.issued2022-01-01
dc.description.abstract© TÜBİTAK.Background/aim: Rheumatoid pulmonary nodule can be detected in up to 32% of rheumatoid arthritis (RA) patients and approximately one-third of nodules may cavitate. We aimed to evaluate characteristics of patients with RA developing cavitary pulmonary nodular (CPN) lesions under disease-modifying antirheumatic drugs (DMARDs), follow-up of both cavitary and solid nodules, and their outcome with the treatment. Materials and methods: RA patients who presented with CPN lesions during follow-up were recruited retrospectively in this case series analysis. Total numbers and mean diameters of cavitary and solid nodules in each thorax computed tomography (CT) have been determined and followed up by two experienced pulmonary physicians. Moreover, changes in treatment after the development of the CPN lesions and characteristics of cavitary nodules were collected. Results: Eleven patients with CPN lesions were reported. At the time of CPN diagnosis, more patients were taking leflunomide than methotrexate (81% vs 19%). Half of the patients were receiving biologic therapy and only 18% were taking anti-TNF drugs. After a median of 24 (3–65) months of follow-up, the regression of CPN lesions was determined in 45% (5/11) of patients. Four of these 5 (80%) patients were switched to a treatment regimen without leflunomide and three of them to nonanti-TNF biologic treatment or targeted synthetic DMARDs (tocilizumab, tofacitinib, and rituximab). Conclusion: CPN lesions seen in RA patients are often pulmonary manifestations of the underlying disease; however, one must rule out malignancies or infections. If lesions progress under DMARDs, it is advised to discontinue synthetic DMARDs (LEF/MTX) and switch to another biological DMARD with different modes of action.
dc.identifier.citationAKSOY A., KOCAKAYA D., Yalçinkaya Y., BOZKURTLAR E., KARAKURT S., Eryüksel E., İnanç N., "Outcome of solid and cavitary pulmonary nodules in rheumatoid arthritis patients— case series", Turkish Journal of Medical Sciences, cilt.52, sa.5, ss.1713-1720, 2022
dc.identifier.doi10.55730/1300-0144.5514
dc.identifier.endpage1720
dc.identifier.issn1300-0144
dc.identifier.issue5
dc.identifier.startpage1713
dc.identifier.urihttps://avesis.marmara.edu.tr/api/publication/93202787-17b9-41b7-bbb0-bd739463c93b/file
dc.identifier.urihttps://hdl.handle.net/11424/283841
dc.identifier.volume52
dc.language.isoeng
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectMedicine
dc.subjectHealth Sciences
dc.subjectFundamental Medical Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectTIP, GENEL & DAHİLİ
dc.subjectClinical Medicine (MED)
dc.subjectCLINICAL MEDICINE
dc.subjectMEDICINE, GENERAL & INTERNAL
dc.subjectGenel Tıp
dc.subjectGeneral Medicine
dc.subjectBiologic drugs
dc.subjectcavitary nodule
dc.subjectleflunomide
dc.subjectrheumatoid arthritis
dc.subjectsolid nodule
dc.titleOutcome of solid and cavitary pulmonary nodules in rheumatoid arthritis patients— case series
dc.typearticle
dspace.entity.typePublication
local.avesis.id93202787-17b9-41b7-bbb0-bd739463c93b
local.indexed.atPUBMED
local.indexed.atSCOPUS
local.indexed.atWOS
relation.isAuthorOfPublication8c3b9d86-3f58-4d22-a92a-a6bc58ce5e72
relation.isAuthorOfPublication2343a71e-12cf-42ea-89ed-b222d121f733
relation.isAuthorOfPublicationbe661872-e895-4271-a0b7-82c5368ec000
relation.isAuthorOfPublication9520db73-1133-4294-8202-da397a93980b
relation.isAuthorOfPublicationc963a17b-4775-4dd7-8db7-ea072cc49ef1
relation.isAuthorOfPublication2771cdd6-7c3b-45a8-89fe-a429a2950516
relation.isAuthorOfPublication.latestForDiscovery8c3b9d86-3f58-4d22-a92a-a6bc58ce5e72

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
9.pdf
Size:
470.75 KB
Format:
Adobe Portable Document Format
Download

Collections

Research Outputs