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The effects of partial bilateral lesioning of substantia nigra in a genetic absence epilepsy rat model

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dc.contributor.authorGÜLHAN, REZZAN
dc.contributor.authorONAT, FİLİZ
dc.contributor.authorGÖREN, MEHMET ZAFER
dc.contributor.authorsGÖREN M. Z., GÜLHAN R., ONAT F., Ergün A.
dc.date.accessioned2023-06-01T07:08:56Z
dc.date.available2023-06-01T07:08:56Z
dc.date.issued2002-04-01
dc.description.abstractObjective: \"Genetic Absence Epilepsy Rats from Strasbourg\" (GAERS), an inbred Wistar strain, serve as an experimental venue. These rats generate spontaneous spike-and-wave discharges (SWD) and have increased γ-aminobutyric acid (GABA) levels in the ventrolateral thalamus (VLT). Recently, substantia nigra pars reticulata (SNpr) was reported to act as an endogeneous inhibitory mechanism in the generation, onset and maintenance of various types of seizures. The presence of tonic control exerted by SNpr in absence seizures should also be tested in GAERS. Methods: In this current study, GABA and L-glutamic acid release in VLT of GAERS with partial bilateral electrolytic lesions of SNpr was evaluated by using microdialysis technique with fluorescent detection. Results: GABA levels in VLT were 0.12±0.04 μM and 0.24±0.08 μM in sham-lesioned and SNpr-lesioned GAERS, respectively. L-glutamic acid level was found to be 0.41 5±0.150 μM in sham-lesioned group and 0.324±0.094 μM in SNpr-lesioned GAERS. Statistical analysis revealed no significant difference between sham-lesioned and SNpr-lesioned rats. The number and the duration of SWD were also similar in two groups. Conclusion: These findings show that SNpr does not exert a tonic control in GAERS and we assume that intact SNpr acts as a site that may exert an inhibition on target structures when activated in GAERS.
dc.identifier.citationGÖREN M. Z., GÜLHAN R., ONAT F., Ergün A., "The effects of partial bilateral lesioning of substantia nigra in a genetic absence epilepsy rat model", Marmara Medical Journal, cilt.15, sa.2, ss.79-85, 2002
dc.identifier.endpage85
dc.identifier.issn1019-1941
dc.identifier.issue2
dc.identifier.startpage79
dc.identifier.urihttps://dergipark.org.tr/tr/download/article-file/252832
dc.identifier.urihttps://hdl.handle.net/11424/289824
dc.identifier.volume15
dc.language.isoeng
dc.relation.ispartofMarmara Medical Journal
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectMedicine
dc.subjectHealth Sciences
dc.subjectFundamental Medical Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectTIP, GENEL & DAHİLİ
dc.subjectClinical Medicine (MED)
dc.subjectCLINICAL MEDICINE
dc.subjectMEDICINE, GENERAL & INTERNAL
dc.subjectGenel Tıp
dc.subjectGeneral Medicine
dc.subjectAbsence epilepsy
dc.subjectGABA γ-aminobutyric acid)
dc.subjectGAERS (Genetic Absence Epilepsy Rats from Strasbourg)
dc.subjectMicrodialysis
dc.subjectNigral control of epilepsy
dc.subjectSubstantia nigra
dc.subjectVentrolateral thalamus
dc.subjectGAERS (Genetic Absence Epilepsy Rats from Strasbourg)
dc.subjectGABA (yaminobutyric acid)
dc.subjectSubstantia nigra
dc.subjectVentrolateral thalamus
dc.subjectAbsence epilepsy
dc.subjectMicrodialysis
dc.subjectNigral control of epilepsy
dc.titleThe effects of partial bilateral lesioning of substantia nigra in a genetic absence epilepsy rat model
dc.typearticle
dspace.entity.typePublication
local.avesis.id835b15bc-7cfb-42f1-979a-7fc17bfb8cb0
local.indexed.atSCOPUS
local.indexed.atTRDIZIN
relation.isAuthorOfPublicationc44fef14-869d-4c28-a766-5e080b17c687
relation.isAuthorOfPublicationc359dea3-046f-4397-90d5-62e4bfc31869
relation.isAuthorOfPublicationf91c1cf5-3919-48eb-a772-35abafdc304e
relation.isAuthorOfPublication.latestForDiscoveryc44fef14-869d-4c28-a766-5e080b17c687

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