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A method for determining the grade of osteoporosis based on risk factors in postmenopausal women

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dc.contributor.authorAKYÜZ, GÜLSEREN DERYA
dc.contributor.authorsOfluoglu, D; Gunduz, OH; Bekirolu, N; Kul-Panza, E; Akyuz, G
dc.date.accessioned2022-03-12T17:18:27Z
dc.date.available2022-03-12T17:18:27Z
dc.date.issued2005
dc.description.abstractThe aim of this study was to determine whether the probability of osteoporosis and osteopenia was affected by the risk factors, physical examination findings, or radiological investigations such as spinal X-rays in postmenopausal women. We assessed risk factors such as use of hormone replacement therapy, physical activity level, calcium intake, smoking, caffeine consumption, long-term immobilization, previous history of fracture, family history of fracture, presence of certain systemic diseases (hyperthyroidism or hyperparathyroidism), or use of medications (corticosteroids or others), physical examinations, and presence of vertebral fractures on spinal X-rays. Patients' bone mineral density (BMD) was evaluated using dual energy X-ray absorptiometry (DXA) in the lumbar spine, and we compared the risk factors between osteopenic and osteoporotic women according to DXA. We evaluated 235 postmenopausal women who attended our osteoporosis outpatient clinic. Those patients were divided into two groups as either osteopenic (n=67, mean age: 63.1 years) or osteoporotic (n=168, mean age: 66.2 years) according to WHO criteria. The lumbar spinal (L1-L2) T-score values were -1.5 +/- 0.6 and -3.1 +/- 0.6 in osteopenic and osteoporotic groups, respectively. There were significant differences between the two groups in terms of mean age and lumbar BMD (p=0.009 and p < 0.001, respectively). We also observed that vertebral tenderness on palpation, back pain, and existing vertebral fracture (fx) were significantly different between the osteopenic and osteoporotic groups (p < 0.05). As a result of the statistical analysis, we found an equation to determine osteopenic and osteoporotic women by using those four factors (age, vertebral tenderness on palpation, back pain, and existing vertebral fx) in multivariate stepwise logistic regression. The equation is as follows: Y (DXA) = -2.9024 + 0.044 (age in year) + 0.819 (vertebral fx) + 0.877 (pain) + 1.136 (vertebral tenderness). We can estimate whether a postmenopausal woman is osteopenic or osteoporotic based on these risk factors by using the stepwise logistic regression equation.
dc.identifier.doi10.1007/s10067-005-1110-0
dc.identifier.eissn1434-9949
dc.identifier.issn0770-3198
dc.identifier.pubmed16010446
dc.identifier.urihttps://hdl.handle.net/11424/227964
dc.identifier.wosWOS:000232857700008
dc.language.isoeng
dc.publisherSPRINGER LONDON LTD
dc.relation.ispartofCLINICAL RHEUMATOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectosteopenia
dc.subjectosteoporosis
dc.subjectscreening and diagnosis
dc.subjectvertebral fracture
dc.subjectBONE-MINERAL DENSITY
dc.subjectTHERAPY
dc.subjectHORMONE
dc.subjectMEN
dc.titleA method for determining the grade of osteoporosis based on risk factors in postmenopausal women
dc.typearticle
dspace.entity.typePublication
local.avesis.idd05a8567-8982-44b9-995a-468f498cd47c
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages6
oaire.citation.endPage611
oaire.citation.issue6
oaire.citation.startPage606
oaire.citation.titleCLINICAL RHEUMATOLOGY
oaire.citation.volume24
relation.isAuthorOfPublicationa0d3ad8e-a3dd-44d0-98b7-d3eb31f6a0c9
relation.isAuthorOfPublication.latestForDiscoverya0d3ad8e-a3dd-44d0-98b7-d3eb31f6a0c9

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