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Effect of muscimol on cholinomimetic-induced cardiovascular responses in rats

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dc.contributor.authorsOnat, F; Tellioglu, T; Aker, R; Goren, Z; Iskender, E; Oktay, S
dc.date.accessioned2022-03-12T16:55:58Z
dc.date.available2022-03-12T16:55:58Z
dc.date.issued1998
dc.description.abstractBrain acetylcholine and gamma-aminobutyric acid (GABA) are both involved in the regulation of central cardiovascular control. Despite data from anatomical and electrophysiological experiments characterizing the interaction between central GABAergic and cholinergic neurotransmission, the potential significance of this interaction in central cardiovascular regulation remains unknown. The purpose of this study was to determine whether activation of GABA(A) receptors by intracerebroventricular or intrahypothalamic administration of muscimol affects the cholinergic agonist-induced cardiovascullar responses. All experiments were performed in conscious, Sprague-Dawley rats instrumented with a guide cannula for drug injection and iliac arterial catheters for direct measurement of mean arterial pressure and heart rate. Administration of a cholinergic agonist, carbachol, either intracerebroventricularly or into the dorsomedial hypothalamic nucleus, produced a significant increase in mean arterial pressure, whereas injection of carbachol into the posterior hypothalamic nucleus caused a slight elevation in blood pressure. Pretreatment with muscimol 10 min before administration of carbachol prevented the carbachol-evoked blood pressure changes. On the other hand, carbachol produced variable changes in heart rate, depending on the site of injection. In [H-3]quinuclydinyl benzilate binding experiments, muscimol did not displace the muscarinic radioligand from its binding sites, suggesting that it does not exert any direct antagonistic activity at muscarinic receptors. These results suggest that the dorsomedial hypothalamic nucleus is a potential site of action for microinjected carbachol and that the GABAergic system has an inhibitory influence on cholinergic neurons involved in blood pressure regulation. (C) 1998 Elsevier Science B.V. All rights reserved.
dc.identifier.doi10.1016/S0014-2999(98)00754-7
dc.identifier.issn0014-2999
dc.identifier.pubmed9874168
dc.identifier.urihttps://hdl.handle.net/11424/226617
dc.identifier.wosWOS:000077447200011
dc.language.isoeng
dc.publisherELSEVIER SCIENCE BV
dc.relation.ispartofEUROPEAN JOURNAL OF PHARMACOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectGABA
dc.subject(gamma-aminobutyric)
dc.subjectcholinergic
dc.subjectblood pressure
dc.subjectheart rate
dc.subjectdorsomedial hypothalamic nucleus
dc.subjectposterior hypothalamic nucleus
dc.subjectMUSCARINIC ACETYLCHOLINE-RECEPTORS
dc.subjectPOSTERIOR HYPOTHALAMIC NUCLEUS
dc.subjectBLOOD-PRESSURE
dc.subjectBASAL FOREBRAIN
dc.subjectAV3V REGION
dc.subjectCHOLINERGIC NEURONS
dc.subjectGABAERGIC NEURONS
dc.subjectHYPERTENSION
dc.subjectMODULATION
dc.subjectCARBACHOL
dc.titleEffect of muscimol on cholinomimetic-induced cardiovascular responses in rats
dc.typearticle
dspace.entity.typePublication
local.avesis.id9b6bcde9-0dae-43d9-a696-d665beccb2c3
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages9
oaire.citation.endPage181
oaire.citation.issue2-3
oaire.citation.startPage173
oaire.citation.titleEUROPEAN JOURNAL OF PHARMACOLOGY
oaire.citation.volume362

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