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Antibacterial properties of cationic copolymers as a function of pendant alkyl chain length and degree of quaternization

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dc.contributor.authorABDURRAHMANOĞLU, SUZAN
dc.contributor.authorsGokkaya, Damla; Topuzogullari, Murat; Arasoglu, Tulin; Trabzonlu, Kubra; Ozmen, Mehmet Murat; Abdurrahmanoglu, Suzan
dc.date.accessioned2022-03-12T22:56:31Z
dc.date.available2022-03-12T22:56:31Z
dc.date.issued2021
dc.description.abstractAntibacterial polymers are promising materials in the fight against bacterial infection which is a vital health problem. Among these materials, cationic (co)polymers with quaternary ammonium groups are of great interest and importance as they interact with the bacterial membrane causing cell death. The antibacterial efficacy can be improved by modifying the pendant alkyl groups and charge density of the polycation. In this study, alkylbromides with different chain lengths were used to obtain quaternized poly(4-vinylpyridine-co-N-vinylpyrrolidone) (P(4VP-co-NVP)) copolymers of various positive charge densities and pendent alkyl chain lengths. While the chemical structures of the produced copolymers were characterized by Fourier transform infrared and H-1 NMR spectroscopy, physicochemical properties such as size and zeta potential were measured by dynamic light scattering spectrometry. It was determined that the zeta potentials and hydrodynamic diameters of the samples vary between +10 and +32 mV and 10 and 16 nm, respectively. The antibacterial activity of the copolymers were tested against Escherichia coli and Staphylococcus aureus bacteria by broth microdilution and standard 'plate' count methods. The results revealed that the antibacterial activity of the copolymers against Escherichia coli can be successfully adjusted through varying the chain length of the alkylating agent (hydrophobic chains) and the degree of quaternization (positive charge density). (c) 2020 Society of Chemical Industry
dc.identifier.doi10.1002/pi.6170
dc.identifier.eissn1097-0126
dc.identifier.issn0959-8103
dc.identifier.urihttps://hdl.handle.net/11424/236941
dc.identifier.wosWOS:000604631000001
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofPOLYMER INTERNATIONAL
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectantibacterial
dc.subjectpolycation
dc.subjectquaternization
dc.subject4&#8208
dc.subjectvinylpyridine
dc.subjectN&#8208
dc.subjectvinylpyrrolidone
dc.subjectNANOPARTICLES
dc.subjectPOLY(4-VINYLPYRIDINE)
dc.subjectPOLYMERS
dc.titleAntibacterial properties of cationic copolymers as a function of pendant alkyl chain length and degree of quaternization
dc.typearticle
dspace.entity.typePublication
local.avesis.id5503a706-ba52-4695-9d16-50fe20ee6b13
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages8
oaire.citation.endPage836
oaire.citation.issue6
oaire.citation.startPage829
oaire.citation.titlePOLYMER INTERNATIONAL
oaire.citation.volume70
relation.isAuthorOfPublicationc4f5249d-7638-47df-be54-950af42ffa85
relation.isAuthorOfPublication.latestForDiscoveryc4f5249d-7638-47df-be54-950af42ffa85

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