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Erdosteine prevents colonic inflammation through its antioxidant and free radical scavenging activities

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dc.contributor.authorAKSOY, HALİL
dc.contributor.authorsSener, Goeksel; Aksoy, Halil; Sehirli, Oezer; Yueksel, Meral; Aral, Cenk; Gedik, Nursal; Cetinel, Sule; Yegen, Berrak C.
dc.date.accessioned2022-03-12T17:32:44Z
dc.date.available2022-03-12T17:32:44Z
dc.date.issued2007
dc.description.abstractAfter intracolonic administration of trinitrobenzene sulphonic acid (TNBS), Sprague-Dawley rats were treated orally either with saline or erdosteine (100 mg/kg per day), a sulfhydryl-containing antioxidant, for 3 days. On the 4th day, rats were decapitated and distal colon was removed for the macroscopic and microscopic damage scoring, for the measurement of malondialdehyde (MDA), glutathione (GSH) and collagen levels, myeloperoxidase (MPO) activity, luminol and lucigenin chemiluminescences (CL) and DNA fragmentation. Lactate dehydrogenase (LDH) activity, tumor necrosis factor-alpha, interleukin (IL)-1 beta, IL-6, and antioxidant capacity were assayed in blood samples. Colitis caused significant increases in the colonic CL values, macroscopic and microscopic damage scores, MDA and collagen levels, MPO activity and DNA fragmentation, along with a significant decrease in tissue GSH level. Similarly, serum cytokines and LDH were elevated in the saline-treated colitis group as compared with the control group. On the other hand, erdosteine treatment reversed all these biochemical indices, and histopathologic alterations induced by TNBS, suggesting that erdosteine protects the colonic tissue via its radical scavenging and antioxidant activities.
dc.identifier.doi10.1007/s10620-007-9801-9
dc.identifier.eissn1573-2568
dc.identifier.issn0163-2116
dc.identifier.pubmed17431768
dc.identifier.urihttps://hdl.handle.net/11424/228673
dc.identifier.wosWOS:000248810300015
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofDIGESTIVE DISEASES AND SCIENCES
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjecterdosteine
dc.subjectcolitis
dc.subjectoxidative damage
dc.subjectinflammation
dc.subjectTNBS
dc.subjectTRINITROBENZENE SULFONIC-ACID
dc.subjectSH-METABOLITE-I
dc.subjectINDUCED COLITIS
dc.subjectBOWEL-DISEASE
dc.subjectULCERATIVE-COLITIS
dc.subjectRESPIRATORY BURST
dc.subjectN-ACETYLCYSTEINE
dc.subjectMUCOSAL DAMAGE
dc.subjectNITRIC-OXIDE
dc.subjectDNA-DAMAGE
dc.titleErdosteine prevents colonic inflammation through its antioxidant and free radical scavenging activities
dc.typearticle
dspace.entity.typePublication
local.avesis.idf80356c4-5f18-438c-8d7e-7a5f5540567b
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages11
oaire.citation.endPage2132
oaire.citation.issue9
oaire.citation.startPage2122
oaire.citation.titleDIGESTIVE DISEASES AND SCIENCES
oaire.citation.volume52
relation.isAuthorOfPublication49f7efb2-a70d-4683-b7e3-ec746927265e
relation.isAuthorOfPublication.latestForDiscovery49f7efb2-a70d-4683-b7e3-ec746927265e

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