Publication:
ARE M-CHOLINOCEPTORS OF GUINEA-PIG GALLBLADDER SMOOTH-MUSCLE OF M4 SUBTYPE

Simple item page
dc.contributor.authorONAT, FİLİZ
dc.contributor.authorsOZKUTLU, U; ALICAN, I; KARAHAN, F; ONAT, F; YEGEN, BC; ULUSOY, NB; OKTAY, S
dc.date.accessioned2022-03-12T16:56:19Z
dc.date.available2022-03-12T16:56:19Z
dc.date.issued1993
dc.description.abstractThe antagonism of carbachol-induced contractions of guinea pig gallbladder smooth muscle strips via selective antagonists, methoctramine, HHSiD, pf-HHSiD and DABDMA has been investigated in order to find out the m-cholinoceptor subtype(s) of gallbladder smooth muscle. All m-cholinoceptor antagonists examined, displaced the concentration-response curves to the right parallel in a concentration-dependent manner without affecting the maximum response. Schild analysis of data was consistent with competitive antagonism. -log K(B) values of the antagonists were 7.37 for HHSiD, 7.53 for pf-HHSiD, 6.58 for DABDMA and 7.60 for methoctramine. These results, together with the high affinity of pirenzepine and low affinities of 4-DAMP and AF-DX 116, indicate that the m-cholinoceptors of the guinea pig gallbladder which mediate cholinergic contractions are not of m1-, m2- and m3-subtypes but seem likely to be of m4-subtype.
dc.identifier.doi10.1159/000139061
dc.identifier.issn0031-7012
dc.identifier.pubmed8516380
dc.identifier.urihttps://hdl.handle.net/11424/226729
dc.identifier.wosWOS:A1993LF43900002
dc.language.isoeng
dc.publisherKARGER
dc.relation.ispartofPHARMACOLOGY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectGALLBLADDER
dc.subjectM-CHOLINOCEPTORS
dc.subjectMUSCARINIC RECEPTOR SUBTYPES
dc.subjectHEXAHYDRO-SILA-DIFENIDOL
dc.subjectSELECTIVE ANTAGONISTS
dc.subjectACETYLENIC ANALOGS
dc.subjectBINDING
dc.subjectAFFINITY
dc.subjectILEUM
dc.subjectIDENTIFICATION
dc.subjectENANTIOMERS
dc.subjectINHIBITION
dc.titleARE M-CHOLINOCEPTORS OF GUINEA-PIG GALLBLADDER SMOOTH-MUSCLE OF M4 SUBTYPE
dc.typearticle
dspace.entity.typePublication
local.avesis.id3fb28417-cdf3-42bf-b807-fa1c44b7a05b
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages7
oaire.citation.endPage314
oaire.citation.issue6
oaire.citation.startPage308
oaire.citation.titlePHARMACOLOGY
oaire.citation.volume46
relation.isAuthorOfPublicationc359dea3-046f-4397-90d5-62e4bfc31869
relation.isAuthorOfPublication.latestForDiscoveryc359dea3-046f-4397-90d5-62e4bfc31869

Files

Collections

Research Outputs