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Electroencephalographic differences between WAG/Rij and GAERS rat models of absence epilepsy

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dc.contributor.authorONAT, FİLİZ
dc.contributor.authorsAkman, Ozlem; Demiralp, Tamer; Ates, Nurbay; Onat, Filiz Yilmaz
dc.date.accessioned2022-03-12T17:48:58Z
dc.date.available2022-03-12T17:48:58Z
dc.date.issued2010
dc.description.abstractThe inbred Wistar Albino Glaxo Rats from Rijswijk (WAG/Rij) and the Genetic Absence Epilepsy Rats from Strasbourg (GAERS) are well-validated genetic models of absence epilepsy. Although they share similar characteristics including the spike-and-wave discharges (SWDs) in the EEG, some differences have been reported between both strains. This study aimed a systematic and detailed comparison of the SWD patterns of both strains in terms of the intensity, frequency and waveform morphology of the discharges by using exactly the same measurement and analysis techniques. The number, cumulative total duration and mean duration of SWDs were significantly higher in GAERS compared to WAG/Rij, while the discharge frequency was higher in the WAG/Rij. Furthermore, SWDs spectra and average SWD waveforms indicated that a single cycle of the SWD contains more energy in faster components such as spike and late positive transient in the GAERS. Additionally, WAG/Rij exhibited a significantly higher power between 8 and 14 Hz during the pre-SWD period. These clear phenomenological differences in the EEGs of both animal models suggest that these variables may represent basic phenotypic features of SWDs that should be sought after in the future studies that explore the genetic and molecular basis of absence epilepsy. (C) 2009 Elsevier B.V. All rights reserved.
dc.identifier.doi10.1016/j.eplepsyres.2009.12.005
dc.identifier.eissn1872-6844
dc.identifier.issn0920-1211
dc.identifier.pubmed20092980
dc.identifier.urihttps://hdl.handle.net/11424/230038
dc.identifier.wosWOS:000277872900003
dc.language.isoeng
dc.publisherELSEVIER
dc.relation.ispartofEPILEPSY RESEARCH
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectWAG/Rij
dc.subjectGAERS
dc.subjectSpike-and-wave discharges
dc.subjectPower spectrum
dc.subjectFrequency domain
dc.subjectWaveform morphology
dc.subjectSPIKE-WAVE DISCHARGES
dc.subjectIDIOPATHIC GENERALIZED EPILEPSY
dc.subjectGENETIC MODEL
dc.subjectSEIZURES
dc.subjectEEG
dc.subjectMECHANISMS
dc.subjectPHENOTYPES
dc.subjectTHALAMUS
dc.subjectSTRAIN
dc.titleElectroencephalographic differences between WAG/Rij and GAERS rat models of absence epilepsy
dc.typearticle
dspace.entity.typePublication
local.avesis.id0009eb34-e767-446a-9a0d-29823a4e84d3
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages9
oaire.citation.endPage193
oaire.citation.issue2-3
oaire.citation.startPage185
oaire.citation.titleEPILEPSY RESEARCH
oaire.citation.volume89
relation.isAuthorOfPublicationc359dea3-046f-4397-90d5-62e4bfc31869
relation.isAuthorOfPublication.latestForDiscoveryc359dea3-046f-4397-90d5-62e4bfc31869

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