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Development of Satureja cuneifolia-loaded sodium alginate/polyethylene glycol scaffolds produced by 3D-printing technology as a diabetic wound dressing material

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dc.contributor.authorOKTAR, FAİK NÜZHET
dc.contributor.authorsIlhan, Elif; Cesur, Sumeyye; Guler, Ece; Topal, Fadime; Albayrak, Deniz; Guncu, Mehmet Mucahit; Cam, Muhammet Emin; Taskin, Turgut; Sasmazel, Hilal Turkoglu; Aksu, Burak; Oktar, Faik Nuzhet; Gunduz, Oguzhan
dc.date.accessioned2022-03-12T22:44:22Z
dc.date.available2022-03-12T22:44:22Z
dc.date.issued2020
dc.description.abstractAcute wounds are a common health problem, with millions of people affected and decreased granulation tissue formation and vascularization, it is also a big challenge for wound care researchers to promote acute wound healing around the globe. This study aims to produce and characterize Satureja cuneifolia plant extract (SC) blended with sodium alginate (SA) /polyethylene glycol (PEG) scaffolds for the potential treatment of diabetic ulcer. SA/PEG scaffolds were prepared by adding different concentrations (1, 3, and 5 wt%) of PEG to 9 wt% SA. The morphological and chemical composition of the resulting 3D printed composite scaffolds was determined using scanning electron microscopy (SEM) and Fourier transforms infrared spectroscopy (FTIR), respectively. Mechanical and thermal properties, swelling, and degradation behaviours were also investigated. The release kinetics of SC were performed. The antimicrobial analysis was evaluated against Escherichia coli and Staphylococcus aureus strains. 3D printed scaffolds have shown an excellent antibacterial effect, especially against gram-positive bacteria due to the antibacterial SC extract they contain. Furthermore, the cell viability of fibroblast (L929) cells on/within scaffolds were determined by the colourimetric MTT assay. The SA/PEG/SC scaffolds show a great promising potential candidate for diabetic wound healing and against bacterial infections. (c) 2020 Elsevier B.V. All rights reserved.
dc.identifier.doi10.1016/j.ijbiomac.2020.06.086
dc.identifier.eissn1879-0003
dc.identifier.issn0141-8130
dc.identifier.pubmed32544577
dc.identifier.urihttps://hdl.handle.net/11424/236423
dc.identifier.wosWOS:000571205200005
dc.language.isoeng
dc.publisherELSEVIER
dc.relation.ispartofINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTissue engineering scaffolds
dc.subject3D printing
dc.subjectDiabetic wound healing
dc.subjectSatureja cuneifolia
dc.subjectESSENTIAL OILS
dc.subjectIN-VITRO
dc.subjectALGINATE
dc.subjectFIBROBLASTS
dc.subjectDEGRADATION
dc.subjectDELIVERY
dc.subjectCELLS
dc.subjectMODEL
dc.titleDevelopment of Satureja cuneifolia-loaded sodium alginate/polyethylene glycol scaffolds produced by 3D-printing technology as a diabetic wound dressing material
dc.typearticle
dspace.entity.typePublication
local.avesis.idcf713a75-5d2e-43f2-b92d-591a3c91b8ed
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages15
local.journal.quartileQ1
oaire.citation.endPage1054
oaire.citation.startPage1040
oaire.citation.titleINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
oaire.citation.volume161
relation.isAuthorOfPublication5ba0a0e0-ebae-43a6-855c-0aabb90021f4
relation.isAuthorOfPublication.latestForDiscovery5ba0a0e0-ebae-43a6-855c-0aabb90021f4

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