Publication:
COVID-19 in hospitalized lung and non-lung solid organ transplant recipients: A comparative analysis from a multicenter study

Simple item page
dc.contributor.authorVELİOĞLU, ARZU
dc.contributor.authorsHeldman, Madeleine R.; Kates, Olivia S.; Safa, Kassem; Kotton, Camille N.; Georgia, Sarah J.; Steinbrink, Julie M.; Alexander, Barbara D.; Hemmersbach-Miller, Marion; Blumberg, Emily A.; Crespo, Maria M.; Multani, Ashrit; Lewis, Angelica, V; Beaird, Omer Eugene; Haydel, Brandy; La Hoz, Ricardo M.; Moni, Lisset; Condor, Yesabeli; Flores, Sandra; Munoz, Carlos G.; Guitierrez, Juan; Diaz, Esther, I; Diaz, Daniela; Vianna, Rodrigo; Guerra, Giselle; Loebe, Matthias; Rakita, Robert M.; Malinis, Maricar; Azar, Marwan M.; Hemmige, Vagish; McCort, Margaret E.; Chaudhry, Zohra S.; Singh, Pooja; Hughes, Kailey; Velioglu, Arzu; Yabu, Julie M.; Morillis, Jose A.; Mehta, Sapna A.; Tanna, Sajal D.; Ison, Michael G.; Tomic, Rade; Derenge, Ariella Candace; van Duin, David; Maximin, Adrienne; Gilbert, Carlene; Goldman, Jason D.; Sehgal, Sameep; Weisshaar, Dana; Girgis, Reda E.; Nelson, Joanna; Lease, Erika D.; Limaye, Ajit P.; Fisher, Cynthia E.
dc.date.accessioned2022-03-14T09:56:16Z
dc.date.available2022-03-14T09:56:16Z
dc.date.issued2021-08
dc.description.abstractLung transplant recipients (LTR) with coronavirus disease 2019 (COVID-19) may have higher mortality than non-lung solid organ transplant recipients (SOTR), but direct comparisons are limited. Risk factors for mortality specifically in LTR have not been explored. We performed a multicenter cohort study of adult SOTR with COVID-19 to compare mortality by 28 days between hospitalized LTR and non-lung SOTR. Multivariable logistic regression models were used to assess comorbidity-adjusted mortality among LTR vs. non-lung SOTR and to determine risk factors for death in LTR. Of 1,616 SOTR with COVID-19, 1,081 (66%) were hospitalized including 120/159 (75%) LTR and 961/1457 (66%) non-lung SOTR (p = .02). Mortality was higher among LTR compared to non-lung SOTR (24% vs. 16%, respectively, p = .032), and lung transplant was independently associated with death after adjusting for age and comorbidities (aOR 1.7, 95% CI 1.0-2.6, p = .04). Among LTR, chronic lung allograft dysfunction (aOR 3.3, 95% CI 1.0-11.3, p = .05) was the only independent risk factor for mortality and age >65 years, heart failure and obesity were not independently associated with death. Among SOTR hospitalized for COVID-19, LTR had higher mortality than non-lung SOTR. In LTR, chronic allograft dysfunction was independently associated with mortality.
dc.identifier.doi10.1111/ajt.16692
dc.identifier.eissn1600-6143
dc.identifier.issn1600-6135
dc.identifier.pubmed34008917
dc.identifier.urihttps://hdl.handle.net/11424/243711
dc.identifier.wosWOS:000677206200001
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofAMERICAN JOURNAL OF TRANSPLANTATION
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectclinical research
dc.subjectpractice
dc.subjectinfection and infectious agents
dc.subjectviral
dc.subjectinfectious disease
dc.subjectlung (allograft) function
dc.subjectdysfunction
dc.subjectlung disease
dc.subjectinfectious
dc.subjectlung transplantation
dc.subjectpulmonology
dc.subjectorgan transplantation in general
dc.titleCOVID-19 in hospitalized lung and non-lung solid organ transplant recipients: A comparative analysis from a multicenter study
dc.typearticle
dspace.entity.typePublication
local.avesis.idcd5d6ad9-c5df-4ca7-8055-f18a3ae6358f
local.import.packageSS16
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages11
oaire.citation.endPage2784
oaire.citation.issue8
oaire.citation.startPage2774
oaire.citation.titleAMERICAN JOURNAL OF TRANSPLANTATION
oaire.citation.volume21
relation.isAuthorOfPublicationa7410f0e-0eb4-4b83-ad61-a71dfbee164f
relation.isAuthorOfPublication.latestForDiscoverya7410f0e-0eb4-4b83-ad61-a71dfbee164f

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Heldman et al. - 2021 - COVID‐19 in hospitalized lung and non‐lung solid o.pdf
Size:
695.43 KB
Format:
Adobe Portable Document Format
Download

Collections

Research Outputs