Publication: Low serm Fibroblast Growth Factor-21 levels is not associated with Carotid intima-media thickness in acromegaly patients
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Date
2022-07-01
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Introduction Elevated fibroblast growth factor-21 (FGF-21) levels are related to carotid intima-media thickness (CIMT), a well-established marker of atherosclerosis. Acromegaly has also been linked to increased CIMT. There has been no data considering the association between FGF-21 levels and atherosclerosis in acromegaly patients. This study aimed to evaluate FGF-21 levels and CIMT in acromegalic patients in relation to atherosclerotic complications. Design Case-control study. Materials and methods The study group included 70 acromegaly patients and 72 healthy volunteers from the Department of Endocrinology and Metabolism Disease, Marmara University Medical School. FGF-21, growth hormone, insulin-like growth factor I, lipids, glucose, insulin levels were assessed. CIMT was measured from the common carotid artery wall on B-mode ultrasound. Results Median FGF-21 levels were significantly lower in the acromegaly group than in the control group. CIMT was higher in acromegaly patients compared to controls. Although there was no correlation between FGF-21 levels and CIMT in patients with acromegaly, a positive correlation was found between high-density lipoprotein-cholesterol and FGF-21 levels. Glucose metabolic markers were the determining factors of the FGF-21 levels in acromegaly patients. Conclusion Our study is the first to examine the relationship between serum FGF-21 levels and atherosclerosis in acromegaly patients. The lower serum FGF-21 levels in acromegaly subjects might be associated with the improving effects of growth hormone on liver fat. Acromegaly was linked to higher CIMT, but there was no correlation between FGF-21 levels and CIMT. The role of FGF-21 in acromegaly as a marker of atherosclerosis requires additional research.
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Tıp, Sağlık Bilimleri, Dahili Tıp Bilimleri, İç Hastalıkları, Endokrinoloji ve Metabolizma Hastalıkları, Medicine, Health Sciences, Internal Medicine Sciences, Internal Diseases, Endocrinology and Metabolic Diseases, ENDOKRİNOLOJİ VE METABOLİZMA, Klinik Tıp, Klinik Tıp (MED), ENDOCRINOLOGY & METABOLISM, CLINICAL MEDICINE, Clinical Medicine (MED), Endocrinology, Endocrine and Autonomic Systems, Endocrinology, Diabetes and Metabolism, Life Sciences, Acromegaly, Atherosclerosis, FGF-21, IGF-1, Carotid intima-media thickness, Cardiovascular disease, DIABETES-MELLITUS, FACTOR-I, HORMONE, LIVER, ATHEROSCLEROSIS, TRANSCRIPTION, PLAQUE, GENE
Citation
Uygur M. M., Yazici D. D., YAVUZ D., "Low serm Fibroblast Growth Factor-21 levels is not associated with Carotid intima-media thickness in acromegaly patients", JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, cilt.45, ss.1405-1412, 2022