Publication: Empirical cefepime+vancomycin versus ceftazidime+vancomycin versus meropenem+vancomycin in the treatment of healthcare-associated meningitis: results of the multicenter ephesus study
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Date
2023-09-28
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Abstract
BACKGROUND: Herein, we analyzed the efficacy of main antibiotic therapy regimens in the treatment of healthcare-associated meningitis (HCAM). MATERIALS/METHODS: This retrospective cohort study was conducted in 18 tertiary-care academic hospitals Turkey, India, Egypt and Romania. We extracted data and outcomes of all patients with post-neurosurgical meningitis cases fulfilling the study inclusion criteria and treated with empirical therapy between December 2006-September 2018. RESULTS: Twenty patients in the cefepime + vancomycin-(CV) group, 31 patients in the ceftazidime + vancomycin-(CFV) group, and 119 patients in the meropenem + vancomycin-(MV) group met the inclusion criteria. The MV subgroup had a significantly higher mean Glasgow Coma Score, a higher rate of admission to the intensive care unit within the previous month, and a higher rate of antibiot herapy within the previous month before the meningitis episode (p 0.05) among the three cohorts. No regimen was effective against carbapenem-resistant bacteria, and vancomycin resulted in an EOT clinical success rate of 60.6% in the methicillin-resistant staphylococci or ampicillin-resistant enterococci subgroup (n = 34). CONCLUSIONS: Our study showed no significant difference in terms of clinical success and mortality among the three treatment options. All regimens were ineffective against carbapenem-resistant bacteria. Vancomycin was unsuccessful in approximately 40% of cases involving methicillin-resistant staphylococci or ampicillin-resistant enterococci.
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Yaşam Bilimleri, Temel Bilimler, Life Sciences, Natural Sciences, Yaşam Bilimleri (LIFE), İmmünoloji, BULAŞICI HASTALIKLAR, Life Sciences (LIFE), IMMUNOLOGY, INFECTIOUS DISEASES, Bulaşıcı hastalıklar, Sağlık Bilimleri, Infectious Diseases, Health Sciences, Antibiotics, Empirical therapy, Glycopeptides, Healthcare-associated meningitis, Multicenter study
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Sipahi O. R., Akyol D., Ormen B., Cicek-Senturk G., Mermer S., ÖNAL U., Amer F., Saed M. A., Ozdemir K., Tukenmez-Tigen E., et al., "Empirical cefepime+vancomycin versus ceftazidime+vancomycin versus meropenem+vancomycin in the treatment of healthcare-associated meningitis: results of the multicenter ephesus study", BMC infectious diseases, cilt.23, sa.1, ss.639, 2023