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Modern and traditional extraction techniques affect chemical composition and bioactivity of Tanacetum parthenium (L.) Sch.Bip

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dc.contributor.authorDOĞAN, AHMET
dc.contributor.authorsZengin, Gokhan; Cvetanovic, Aleksandra; Gasic, Uros; Stupar, Alena; Bulut, Gizem; Senkardes, Ismail; Dogan, Ahmet; Sinan, Kouadio Ibrahime; Uysal, Sengul; Aumeeruddy-Elalfi, Zaahira; Aktumsek, Abdurrahman; Mahomoodally, Mohamad Fawzi
dc.date.accessioned2022-03-12T22:54:53Z
dc.date.available2022-03-12T22:54:53Z
dc.date.issued2020
dc.description.abstractTanacetum parthenium (L.) Sch.Bip (TP), a flowering plant, is famous in traditional medicine to prevent migraine and headache. However, there is currently a dearth of studies to advocate the phytochemical profile and biological propensities of extracts prepared from this plant. This study endeavors to highlight the biological potential of TP extracts prepared by modern (ultrasound-UAE, microwave-MAE and accelerated-ASE extractions) and traditional (maceration and Soxhlet) extraction techniques. The chemical profile of the extracts was established via ultra-high-pressure liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) technique. Sixty different polyphenolic compounds belonging to the classes of phenolic acids, flavonoid glycosides and flavonoid aglycones were recorded in the extracts. Additionally, the quantity of 17 components was measured using appropriate standards and it was found that the modern extraction gave extracts with the higher content of observed compounds than the traditional techniques. Evaluation of antioxidant activity was determined in vitro via five standard assays. The inhibitory potential of TP extracts against key enzymes implicated in the noncommunicable diseases such as diabetes (alpha-amylase and alpha-glucosidase), neurodegenerative diseases (acetyl- and butyrylcholinesterase) and skin diseases (tyrosinase), was assessed. Potent antioxidant ability of all TP extract was revealed with a predominance for the extracts yielded using the ASE method. This potent antioxidant activity of the extracts corroborated with the high phenolic (65.05 +/- 0.27 mg gallic acid equivalent (GAE)/g extract) and flavonoid contents (55A0 +/- 0.52 mg rutin equivalent (RE)/g extract). Tanacetum partheniwn extracts also showed significant alpha-glucosidase inhibitory activity (1.63-1.67 mmol acarbose equivalent (ACAE)/g extract) and moderate inhibition activity against a-amylase (0.51-0.56 mmol ACAE/g extract). The extracts also showed potent activity against cholinesterases and tyrosinase. This study tend to validate the use of TP extracts obtained by novel extraction techniques such as ASE, as potent bioactive extracts to be further studied for therapeutic bio-product development.
dc.identifier.doi10.1016/j.indcrop.2020.112202
dc.identifier.eissn1872-633X
dc.identifier.issn0926-6690
dc.identifier.urihttps://hdl.handle.net/11424/236564
dc.identifier.wosWOS:000519335100011
dc.language.isoeng
dc.publisherELSEVIER
dc.relation.ispartofINDUSTRIAL CROPS AND PRODUCTS
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectFeverfew
dc.subjectAntioxidant
dc.subjectPhenolics
dc.subjectPhytochemicals
dc.subjectNovel agents
dc.subjectANTIOXIDANT ACTIVITIES
dc.subjectASPHODELINE-ANATOLICA
dc.subjectMIGRAINE PROPHYLAXIS
dc.subjectFEVERFEW
dc.subjectFLAVONOIDS
dc.subjectINHIBITORS
dc.subjectMS/MS
dc.titleModern and traditional extraction techniques affect chemical composition and bioactivity of Tanacetum parthenium (L.) Sch.Bip
dc.typearticle
dspace.entity.typePublication
local.avesis.id865c6889-b7b0-4445-bf7a-166ab83ea421
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.articlenumber112202
local.journal.numberofpages10
local.journal.quartileQ1
oaire.citation.titleINDUSTRIAL CROPS AND PRODUCTS
oaire.citation.volume146
relation.isAuthorOfPublication34e928c8-270a-41b3-8311-23fba8b897ed
relation.isAuthorOfPublication.latestForDiscovery34e928c8-270a-41b3-8311-23fba8b897ed

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