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The impact of platelet functions and inflammatory status on the severity of preeclampsia

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dc.contributor.authorBİNGÖL ÖZAKPINAR, ÖZLEM
dc.contributor.authorsSahin, Sadik; Ozakpinar, Ozlem Bingol; Eroglu, Mustafa; Tulunay, Aysin; Ciraci, Enver; Uras, Fikriye; Tetik, Sermin
dc.date.accessioned2022-03-13T12:49:07Z
dc.date.available2022-03-13T12:49:07Z
dc.date.issued2015
dc.description.abstractObjective: To find out whether there is a correlation between the extent of platelet activation and inflammation and the severity of preeclampsia (PE) in the third trimester of pregnancy. Methods: Forty-one women with PE (n = 23 severe, n = 18 mild) and 80 normotensive pregnant (NP) women were included in the study. Their blood samples were obtained and interleukin (IL)-8 and IL-10 levels measured by an enzyme-linked immunosorbent assay. Basal CD61 and CD62P expressions on CD41-positive platelets were analyzed with the use of flow-cytometry. Platelet aggregation was induced by adenosine diphosphate and determined by aggregometry. Results: CD62P expression was increased in severely preeclamptic women, and the platelet aggregation was decreased in both mildly and severely preeclamptic women in comparison with NP women. However, CD61 expression was similar among the groups. An enhanced inflammatory response was seen in severely preeclamptic women demonstrated by increased levels of IL-8 and decreased levels of IL-10. However, the intensity of platelet activation did not correlate directly with the change in plasma levels of IL-8 and IL-10 in preeclamptic women. Conclusions: Platelets may have a role in the inflammatory response in PE. However, the severity of inflammation is found to be independent from the intensity of platelet activation in preeclamptic women. This seems to be related to mechanisms causing alterations of cytokine levels such as IL-8 and IL-10, rather than platelet activation.
dc.identifier.doi10.3109/14767058.2014.927860
dc.identifier.eissn1476-4954
dc.identifier.issn1476-7058
dc.identifier.pubmed24853491
dc.identifier.urihttps://hdl.handle.net/11424/238261
dc.identifier.wosWOS:000354606400006
dc.language.isoeng
dc.publisherTAYLOR & FRANCIS LTD
dc.relation.ispartofJOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAggregometry
dc.subjectinflammation
dc.subjectinterleukins
dc.subjectplatelet activation
dc.subjectpreeclampsia
dc.subjectseverity
dc.subjectNORMAL-PREGNANCY
dc.subjectPLASMA-LEVELS
dc.subjectAGGREGATION
dc.subjectACTIVATION
dc.subjectEXPRESSION
dc.subjectCYTOKINES
dc.subjectIL-10
dc.subjectINTERLEUKIN-10
dc.subjectADHESION
dc.subjectGMP-140
dc.titleThe impact of platelet functions and inflammatory status on the severity of preeclampsia
dc.typearticle
dspace.entity.typePublication
local.avesis.id1c066bbe-ebe1-414a-9542-8b677b272bce
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages6
oaire.citation.endPage648
oaire.citation.issue6
oaire.citation.startPage643
oaire.citation.titleJOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
oaire.citation.volume28
relation.isAuthorOfPublication44b61e5d-4045-4d63-926e-2f01c3ee5642
relation.isAuthorOfPublication.latestForDiscovery44b61e5d-4045-4d63-926e-2f01c3ee5642

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