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The utility of heart-type free fatty-acid binding-protein (HFABP) levels for differentiating acute ischemic stroke from stroke mimics

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dc.contributor.authorAKOĞLU, HALDUN
dc.contributor.authorSANRI, ERKMAN
dc.contributor.authorKARACABEY, SİNAN
dc.contributor.authorEFEOĞLU, MELİS
dc.contributor.authorDENİZBAŞI ALTINOK, ARZU
dc.contributor.authorsUnal E., AKOĞLU H., SANRI E., KARACABEY S., EFEOĞLU SAÇAK M., Onur O., DENİZBAŞI ALTINOK A.
dc.date.accessioned2023-09-18T10:55:36Z
dc.date.available2023-09-18T10:55:36Z
dc.date.issued2023-01-01
dc.description.abstractBackground: Heart-type fatty acid-binding protein (HFABP) is found in the myocardium, brain, and some organs and is rapidly released from damaged cells into the circulation in case of ischemia. Aims: We aimed to determine the diagnostic utility of HFABP levels in patients suggesting acute ischemic stroke (AIS). Methods: This study was a prospective, single-center, observational diagnostic accuracy study with a nested cohort design. The estimated sample size was 126 patients, with a 1:1 case and control ratio. We included all consecutive patients with a lateralizing symptom (motor or sensory) or finding suggesting AIS (139 patients) who presented to ED within 24 h of their symptom onset and collected plasma at admission to the ED. After further evaluations, 111 patients (79.8%) were diagnosed with AIS and 28 with other neurological diseases (stroke-mimics). Findings: In our study, the median HFABP levels of the cases and controls were 2.6 μg/ml and 2.2 μg/ml, respectively, without any statistically significant difference (p = 0.120). The diagnostic accuracy of HFABP for AIS was also insignificant at 0.60 (95% CI 0.51–0.68; p = 0.119). Discussion: Plasma HFABP level is not a marker that can differentiate AIS from other neurological pathologies in patients presenting to the ED, with findings suggesting AIS.
dc.identifier.citationUnal E., AKOĞLU H., SANRI E., KARACABEY S., EFEOĞLU SAÇAK M., Onur O., DENİZBAŞI ALTINOK A., "The utility of heart-type free fatty-acid binding-protein (HFABP) levels for differentiating acute ischemic stroke from stroke mimics", Acta Neurologica Belgica, 2023
dc.identifier.doi10.1007/s13760-023-02372-1
dc.identifier.issn0300-9009
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85169828155&origin=inward
dc.identifier.urihttps://hdl.handle.net/11424/293501
dc.language.isoeng
dc.relation.ispartofActa Neurologica Belgica
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectNöroloji
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectInternal Medicine Sciences
dc.subjectNeurology
dc.subjectHealth Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectKLİNİK NÖROLOJİ
dc.subjectClinical Medicine (MED)
dc.subjectCLINICAL MEDICINE
dc.subjectCLINICAL NEUROLOGY
dc.subjectNöroloji (klinik)
dc.subjectNeurology (clinical)
dc.subjectDiagnosis
dc.subjectStroke
dc.subjectThe heart-type fatty acid-binding protein
dc.titleThe utility of heart-type free fatty-acid binding-protein (HFABP) levels for differentiating acute ischemic stroke from stroke mimics
dc.typearticle
dspace.entity.typePublication
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local.indexed.atPUBMED
local.indexed.atSCOPUS
local.indexed.atWOS
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relation.isAuthorOfPublication.latestForDiscovery9a8731a7-4cee-4fe1-9789-97dcb6ab6bce

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