Publication:
Investigation of possible neuroprotective effects of some plant extracts on brain in bile duct ligated rats

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dc.contributor.authorŞEN, ALİ
dc.contributor.authorsOzel, Armagan Begum; Cilingir-Kaya, Ozlem Tugce; Sener, Goksel; Ozbeyli, Dilek; Sen, Ali; Sacan, Ozlem; Yanardag, Refiye; Yarat, Aysen
dc.date.accessioned2022-03-12T22:57:26Z
dc.date.available2022-03-12T22:57:26Z
dc.date.issued2021
dc.description.abstractThis study aimed to investigate the possible neuroprotective effects of bitter melon (BM), chard, and parsley extracts on oxidative damage that may occur in the brain of rats with bile duct ligation (BDL)-induced biliary cirrhosis. It was observed that lipid peroxidation (LPO), sialic acid (SA), and nitric oxide (NO) levels increased; glutathione (GSH) levels, catalase (CAT) activity, and tissue factor (TF) activity decreased significantly in the BDL group. However, in groups with BDL given BM, chard, and parsley extracts LPO, SA, NO levels decreased; GSH levels and CAT activities increased significantly. No significant differences were observed between groups in total protein, glutathione-S-transferase, superoxide dismutase, and boron. Histological findings were supported by the biochemical results. BM, chard, and parsley extracts were effective in the regression of oxidant damage caused by cirrhosis in the brain tissues. Practical applications Bitter melon (BM), chard, and parsley have antioxidant properties due to their bioactive compounds which are involved in scavenging free radicals, suppressing their production, and stimulating the production of endogenous antioxidant compounds. Since BM, chard, and parsley extracts were found to be effective in the regression of oxidant damage caused by cirrhosis in the brain tissues, these plant extracts may be an alternative in the development of different treatment approaches against brain damage in cirrhosis. At the same time, these species have been used as food by the people for many years. Therefore, they can be used safely as neuroprotective agents in treatment.
dc.identifier.doi10.1111/jfbc.13835
dc.identifier.eissn1745-4514
dc.identifier.issn0145-8884
dc.identifier.pubmed34173678
dc.identifier.urihttps://hdl.handle.net/11424/237041
dc.identifier.wosWOS:000667435200001
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofJOURNAL OF FOOD BIOCHEMISTRY
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectbile duct ligation
dc.subjectbitter melon
dc.subjectbrain
dc.subjectchard
dc.subjectparsley
dc.subjectBETA-VULGARIS L.
dc.subjectINDUCED OXIDATIVE STRESS
dc.subjectPETROSELINUM-CRISPUM
dc.subjectMOMORDICA-CHARANTIA
dc.subjectHEPATIC-ENCEPHALOPATHY
dc.subjectOBSTRUCTIVE-JAUNDICE
dc.subjectANTIOXIDANT ACTIVITY
dc.subjectPHENOLIC-COMPOUNDS
dc.subjectMEMORY DEFICITS
dc.subjectLIVER-CIRRHOSIS
dc.titleInvestigation of possible neuroprotective effects of some plant extracts on brain in bile duct ligated rats
dc.typearticle
dspace.entity.typePublication
local.avesis.id66241307-788b-4c3e-947d-afe71109cf32
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.articlenumbere13835
local.journal.numberofpages12
oaire.citation.issue8
oaire.citation.titleJOURNAL OF FOOD BIOCHEMISTRY
oaire.citation.volume45
relation.isAuthorOfPublication9e088078-d757-41a4-afc6-909f32031cb1
relation.isAuthorOfPublication.latestForDiscovery9e088078-d757-41a4-afc6-909f32031cb1

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