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Erdosteine treatment attenuates oxidative stress and fibrosis in experimental biliary obstruction

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dc.contributor.authorERCAN, FERİHA
dc.contributor.authorsSener, Goeksel; Sehirli, A. Ozer; Toklu, Hale Z.; Yuksel, Meral; Ercan, Feriha; Gedik, Nursal
dc.date.accessioned2022-03-12T17:32:47Z
dc.date.available2022-03-12T17:32:47Z
dc.date.issued2007
dc.description.abstractOxidative stress, in particular lipid peroxidation, induces collagen synthesis and causes fibrosis. The aim of this study was to assess the antioxidant and antifibrotic effects of erdosteine on liver fibrosis induced by biliary obstruction in rats. Liver fibrosis was induced in Wistar albino rats by bile duct ligation (BDL). Erdosteine (10 mg/kg, orally) or saline was administered for 28 days. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH) levels were determined to assess liver functions and tissue damage, respectively. Pro-inflammatory cytokines, TNF-alpha, IL-1 beta and IL-6 and antioxidant capacity (AOC) were assayed in plasma samples. Liver tissues were taken for determination of malondialdehyde (MDA) and glutathione (GSH) levels, myeloperoxidase (MPO) activity and collagen content. Production of reactive oxidants was monitored by chemiluminescence assay. Serum AST, ALT, LDH, and plasma cytokines were elevated in the BDL group as compared to controls and were significantly decreased by erdosteine treatment. Hepatic GSH level and plasma AOC, depressed by BDL, were elevated back to control level with erdosteine treatment. Furthermore, hepatic luminol and lucigenin chemiluminescence (CL), MDA level, MPO activity and collagen content in BDL group increased dramatically compared to control and reduced by erdosteine treatment. Since erdosteine administration alleviated the BDL-induced oxidative injury of the liver and improved the hepatic functions, it seems likely that erdosteine with its antioxidant and antifibrotic properties, may be of potential therapeutic value in protecting the liver fibrosis and oxidative injury due to biliary obstruction.
dc.identifier.doi10.1007/s00383-006-1872-8
dc.identifier.eissn1437-9813
dc.identifier.issn0179-0358
dc.identifier.pubmed17216233
dc.identifier.urihttps://hdl.handle.net/11424/228688
dc.identifier.wosWOS:000244315500006
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofPEDIATRIC SURGERY INTERNATIONAL
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjecterdosteine
dc.subjectbile duct ligation
dc.subjecthepatic fibrosis
dc.subjectlipid peroxidation
dc.subjectBILE-DUCT LIGATION
dc.subjectVITAMIN-E
dc.subjectN-ACETYLCYSTEINE
dc.subjectHEPATIC-INJURY
dc.subjectNITRIC-OXIDE
dc.subjectRATS
dc.subjectLIVER
dc.subjectCYTOKINES
dc.subjectMYELOPEROXIDASE
dc.subjectACTIVATION
dc.titleErdosteine treatment attenuates oxidative stress and fibrosis in experimental biliary obstruction
dc.typearticle
dspace.entity.typePublication
local.avesis.idee23f468-7f5b-48d1-b82b-4ef78e11cecb
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages9
oaire.citation.endPage241
oaire.citation.issue3
oaire.citation.startPage233
oaire.citation.titlePEDIATRIC SURGERY INTERNATIONAL
oaire.citation.volume23
relation.isAuthorOfPublicationadc800ed-105c-40c7-a572-6cf3f175be92
relation.isAuthorOfPublication.latestForDiscoveryadc800ed-105c-40c7-a572-6cf3f175be92

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