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Microbial composition and non-surgical periodontal treatment of aggressive periodontitis: Two case reports

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dc.contributor.authorDOĞAN, BAŞAK
dc.contributor.authorsDilek MAMAKLIOĞLU;Bahar EREN KURU;Maribasappa KARCHED;BAŞAK DOĞAN
dc.date.accessioned2022-03-15T16:58:54Z
dc.date.available2022-03-15T16:58:54Z
dc.date.issued2019
dc.description.abstractThe objective of this case report was to characterize the subgingival microbiological profiles of two patients with generalized aggressive periodontitis (GAgP) and to evaluatethe clinical outcomes of non-surgical periodontal treatment(NSPT) over a 6-months period. Pooled subgingival samplesof two patients who referred to our clinic and diagnosed withGAgP were collected and analyzed for the presence of 300species/phlotypes using Human Oral Microbe IdentificationMicroarray analysis. NSPT was performed within 3-week period. Clinical parameters were measured at baseline, 3 and6 months after NSPT. Recall visits were performed every 2weeks during the first 3 months and every 4 weeks up to 6months. All samples harboured a total of 61 species and 32species were common in both patients. First patient had 17and the other had 12 distinct species. High levels of Filifactor alocis, Porpyromonas gingivalis, Campylobacter concisusand rectus, Fusobacterium nucleatum and Desulfobulbusspp. were detected in both patients while Aggregatibacter actinomycetemcomitans was found in none of them. Six monthsafter NSPT, all clinical parameters were improved in two A. actinomycetemcomitans-negative GAgP patients. In addition towell-recognized periodontal pathogens the presence of highlevels of Filifactor alocis and Desulfobulbus spp. seem to beassociated with GAgP.
dc.description.abstractBu olgu raporunun amacı iki generalize agresif periodontitis (GAgP) hastasının subgingival mikrobiyolojik profilini belirlemek ve cerrahi olmayan periodontal tedavinin (COPT) 6 aylık klinik sonuçlarını sunmaktır. Kliniğimize başvuran iki GAgP hastasının havuzlama yöntemiyle toplanan subgingival örnekleri, 300 tür/filotipin varlığını belirlemek için Human Oral Microbiome Identificaition Microarray analizi kullanılarak incelendi. COPT 3 hafta içinde uygulandı. Klinik parametreler tedavi öncesi, sonrası 3. ve 6. aylarda kaydedildi. Hastalar, ilk 3 ayda 2 haftada bir, son 3 ayda 4 haftada bir kontrol seanslarına çağırıldı. Tüm örneklerde toplam 61 türe ve iki hastada ortak 32 türe rastlandı. İlk hastada 17, diğer hastada 12 farklı tür tespit edildi. İki hastada da yüksek seviyede Filifactor alocis, Porpyromonas gingivalis, Campylobacter concisus and rectus, Fusobacterium nucleatum and Desulfobulbus spp. saptanırken Aggregatibacter actinomycetemcomitans tespit edilmedi. COPT sonrası altıncı ayda A. actinomycetemcomitans-negatif iki GAgP hastasının tüm klinik parametrelerinde iyileşme olduğu gözlendi. Bilinen periodontal patojenlere ek olarak yüksek seviyedeki Filifactor alocis ve Desulfobulbus spp.’nin varlığının GAgP ile ilişkilendirilebileceği düşünülmüştür.
dc.identifier.doi10.5505/yeditepe.2019.95866
dc.identifier.issn2458-9586;2458-9586
dc.identifier.urihttps://hdl.handle.net/11424/253458
dc.language.isoeng
dc.relation.ispartof7tepe Klinik
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDiş Hekimliği
dc.titleMicrobial composition and non-surgical periodontal treatment of aggressive periodontitis: Two case reports
dc.title.alternativeAgresif periodontitisin mikrobiyal i̇çeriği ve cerrahi olmayan periodontal tedavisi: İki olgu sunumu
dc.typeother
dspace.entity.typePublication
local.avesis.idce4e0f4b-f112-4e3d-bf3c-d8462447c540
local.import.packageSS24
local.import.sourceTRDizin
local.indexed.atTRDIZIN
oaire.citation.endPage 145
oaire.citation.issue1
oaire.citation.startPage140
oaire.citation.title7tepe Klinik
oaire.citation.volume15
relation.isAuthorOfPublicationa2569f78-7a2a-4f98-8cc9-d8b67ae56f6d
relation.isAuthorOfPublication.latestForDiscoverya2569f78-7a2a-4f98-8cc9-d8b67ae56f6d

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