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Dose-dependent effect of Scolymus hispanicus L. (sevketibostan) on ethylene glycol-induced kidney stone disease in rats

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dc.contributor.authorCOŞKUN, ALİ
dc.contributor.authorERTAŞ, BÜŞRA
dc.contributor.authorELÇİOĞLU, HURİYE NURSEL
dc.contributor.authorsCoskun N. K., Coskun A., ERTAŞ B., Ahmad S., Ozdl M. U., ÇANKAYA S., ÇETİNKOL Y., Ozel Y., ELÇİOĞLU H. N.
dc.date.accessioned2023-03-06T10:58:29Z
dc.date.available2023-03-06T10:58:29Z
dc.date.issued2022-01-01
dc.description.abstractKidney stone, also known as calcium oxalate nephrolithiasis, is one of the most common diseases worldwide. Calculi usually forms when urine becomes supersaturated with particular calcium salts such as calcium oxalate. In the present study, we investigated the ameliorative potential of the root extract of the Common golden thistle, Scolymus hispanicus L. (SH) on rats with ethylene glycol (EG) induced kidney stone disease. Sprague-Dawley rats, each weighing 250-300 g, were divided into three groups (n=6 per group): (i) Control (C); (ii) EG; and (iii) EG+SH. To induce nephrolithiasis, the rats received 1% of EG with drinking water, while the C group received normal drinking water during the study. SH extract 2 g/kg was added to the treatment from the 4th week onwards in EG+SH group. At the end of each experiment, rats were decapacitated and serum levels of calcium, magnesium, phosphorus, creatinine, aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) were assessed in all groups at 0, 4, and 8 weeks. Oxalic acid and creatininelevels were measured in urine samples collected at 24 h in metabolic cages. Renal tissues were evaluated histopathologically at the end of the experiment. After 8 weeks, serum creatinine levels were found decreased in the SH group while increased in the EG group. Serum magnesium and AST levels were also found decreased in the EG group, however, SH treatment reversed these values. The SH treatment also increased urinary oxalic acid levels. When the kidney tissue of EG group was examined, there was a high level of crystal/stone, especially in the renal cortex. In kidney tissues of the SH group, only small amounts of crystal/stone were observed. Our experimental findings have demonstrated the ameliorative potential of the aqueous extracts of S. hispanicus roots and shells on EG-induced in the kidney stones in rats. Isolation of active compounds of SH would be desirable to understand the biochemical mechanism behind the process better.
dc.identifier.citationCoskun N. K., Coskun A., ERTAŞ B., Ahmad S., Ozdl M. U., ÇANKAYA S., ÇETİNKOL Y., Ozel Y., ELÇİOĞLU H. N., "Dose-dependent effect of Scolymus hispanicus L. (sevketibostan) on ethylene glycol-induced kidney stone disease in rats", INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS, cilt.59, sa.1, ss.7-13, 2022
dc.identifier.endpage13
dc.identifier.issn0301-1208
dc.identifier.issue1
dc.identifier.startpage7
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000754192700001
dc.identifier.urihttps://hdl.handle.net/11424/287166
dc.identifier.volume59
dc.language.isoeng
dc.relation.ispartofINDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectBiyofizik
dc.subjectBiyokimya
dc.subjectTemel Bilimler
dc.subjectMedicine
dc.subjectLife Sciences
dc.subjectMolecular Biology and Genetics
dc.subjectCytogenetic
dc.subjectHealth Sciences
dc.subjectFundamental Medical Sciences
dc.subjectBiophysics
dc.subjectBiochemistry
dc.subjectNatural Sciences
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectBİYOFİZİK
dc.subjectBiyoloji ve Biyokimya
dc.subjectBIOCHEMISTRY & MOLECULAR BIOLOGY
dc.subjectMOLECULAR BIOLOGY & GENETICS
dc.subjectLife Sciences (LIFE)
dc.subjectBIOPHYSICS
dc.subjectBIOLOGY & BIOCHEMISTRY
dc.subjectİlaç Keşfi
dc.subjectBiyokimya (tıbbi)
dc.subjectYapısal Biyoloji
dc.subjectMoleküler Biyoloji
dc.subjectKlinik Biyokimya
dc.subjectKanser Araştırmaları
dc.subjectYaşlanma
dc.subjectBiyokimya, Genetik ve Moleküler Biyoloji (çeşitli)
dc.subjectGenel Biyokimya, Genetik ve Moleküler Biyoloji
dc.subjectDrug Discovery
dc.subjectBiochemistry (medical)
dc.subjectStructural Biology
dc.subjectMolecular Biology
dc.subjectClinical Biochemistry
dc.subjectCancer Research
dc.subjectAging
dc.subjectBiochemistry, Genetics and Molecular Biology (miscellaneous)
dc.subjectGeneral Biochemistry, Genetics and Molecular Biology
dc.subjectCalcium oxalate
dc.subjectCommon golden thistle
dc.subjectCrystal stone formation
dc.subjectKidney tissue
dc.subjectNephrolithiasis
dc.subjectSpanish oyster thistle
dc.subjectHYPEROXALURIA
dc.subjectANTIOXIDANT
dc.subjectINJURY
dc.subjectCalcium oxalate
dc.subjectCommon golden thistle
dc.subjectCrystal stone formation
dc.subjectKidney tissue
dc.subjectNephrolithiasis
dc.subjectSpanish oyster thistle
dc.titleDose-dependent effect of Scolymus hispanicus L. (sevketibostan) on ethylene glycol-induced kidney stone disease in rats
dc.typearticle
dspace.entity.typePublication
local.avesis.idd69d99ed-aa8b-49f2-9f81-2839283cd5f4
local.indexed.atWOS
local.indexed.atSCOPUS
relation.isAuthorOfPublication97332e74-0913-4eaf-aabd-53ad64ffff04
relation.isAuthorOfPublication864e7cb0-b39f-48bb-a546-ee65ffc807b2
relation.isAuthorOfPublication07b24b61-ed29-42f4-80e5-5d78d14f5e90
relation.isAuthorOfPublication.latestForDiscovery97332e74-0913-4eaf-aabd-53ad64ffff04

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