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Vitamin D receptor and estrogen receptor gene polymorphisms in men with type 2 diabetes: Effects on Bone Metabolism

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dc.contributor.authorÜSTAY, ÖZLEM
dc.contributor.authorYAVUZ, DİLEK
dc.contributor.authorYÜKSEL, MERAL
dc.contributor.authorsYAVUZ D., YÜKSEL M., Sancak S., Yazici D., ÜSTAY Ö., Deyneli O., Akalin S.
dc.date.accessioned2023-07-25T10:47:11Z
dc.date.available2023-07-25T10:47:11Z
dc.date.issued2022-12-01
dc.description.abstractPurpose There is an increased fracture risk in type 2 diabetes mellitus [DM] patients independent of bone mineral density [BMD], both in men and women. Estrogen receptor [ER]-alpha and vitamin D receptor [VDR] gene polymorphisms may predispose patients to increased osteoporosis and fracture risk. This study aims to analyze the relationship of the ER-alpha gene and VDR gene polymorphisms with indicators of bone turnover and BMD in male type 2 diabetic patients. Methods Type 2 diabetic men diagnosed with diabetes for at least one year and healthy controls were included in this cross-sectional study. BMD was measured by dual X ray absorptiometry. Gene polymorphisms were evaluated with polymerase chain reaction-restriction length polymorphism. Serum iPTH, calcium, beta-CrossLaps (cTx), osteocalcin, and free testosterone levels were also evaluated. Results Participants were 141 type 2 diabetic men [55 +/- 8 years] and 100 healthy controls [53 +/- 7 years]. BMD measurements were not statistically different between the groups. While iPTH [p < 0.05] and serum calcium levels [p = 0.03] were higher in men with type 2 DM; beta-CrossLaps [p = 0.0001], osteocalcin [p = 0.005], and free testosterone [p = 0.04] were lower than controls. The differences in terms of the frequencies of VDR Apa, Taq, Bsm, Fok and ER-alpha polymorphisms were not statistically significant between the groups. No relationship was observed between polymorphisms and BMD in both groups. Conclusions VDR and ER-alpha gene polymorphisms seem to have no effect on BMD and bone turnover in men with DM.
dc.identifier.citationYAVUZ D., YÜKSEL M., Sancak S., Yazici D., ÜSTAY Ö., Deyneli O., Akalin S., "Vitamin D receptor and estrogen receptor gene polymorphisms in men with type 2 diabetes: Effects on Bone Metabolism", JOURNAL OF DIABETES AND METABOLIC DISORDERS, cilt.21, sa.2, ss.1293-1299, 2022
dc.identifier.doi10.1007/s40200-022-01048-6
dc.identifier.endpage1299
dc.identifier.issn2251-6581
dc.identifier.issue2
dc.identifier.startpage1293
dc.identifier.urihttps://link.springer.com/article/10.1007/s40200-022-01048-6
dc.identifier.urihttps://hdl.handle.net/11424/291593
dc.identifier.volume21
dc.language.isoeng
dc.relation.ispartofJOURNAL OF DIABETES AND METABOLIC DISORDERS
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectEndokrinoloji ve Metabolizma Hastalıkları
dc.subjectMedicine
dc.subjectHealth Sciences
dc.subjectInternal Medicine Sciences
dc.subjectInternal Diseases
dc.subjectEndocrinology and Metabolic Diseases
dc.subjectENDOKRİNOLOJİ VE METABOLİZMA
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectENDOCRINOLOGY & METABOLISM
dc.subjectCLINICAL MEDICINE
dc.subjectClinical Medicine (MED)
dc.subjectEndokrin ve Otonom Sistemler
dc.subjectEndokrinoloji, Diyabet ve Metabolizma
dc.subjectEndokrinoloji
dc.subjectYaşam Bilimleri
dc.subjectEndocrine and Autonomic Systems
dc.subjectEndocrinology, Diabetes and Metabolism
dc.subjectEndocrinology
dc.subjectLife Sciences
dc.subjectBone density
dc.subjectDiabetes Mellitus
dc.subjecttype 2
dc.subjectMale
dc.subjectPolymorphism
dc.subjectgenetic
dc.subjectReceptors
dc.subjectcalcitriol
dc.subjectEstrogen
dc.subjectMINERAL DENSITY
dc.subjectOSTEOPOROTIC FRACTURES
dc.subjectVERTEBRAL FRACTURES
dc.subjectRISK
dc.subjectTURNOVER
dc.subjectWOMEN
dc.subjectASSOCIATION
dc.subjectGENOTYPES
dc.subjectMELLITUS
dc.subjectMARKERS
dc.subjectDiabetes Mellitus, type 2
dc.subjectPolymorphism, genetic
dc.subjectReceptors, calcitriol
dc.subjectReceptors, Estrogen
dc.titleVitamin D receptor and estrogen receptor gene polymorphisms in men with type 2 diabetes: Effects on Bone Metabolism
dc.typearticle
dspace.entity.typePublication
local.avesis.idd1e2d446-2260-4571-bf6e-793edb77a6be
local.indexed.atWOS
local.indexed.atPUBMED
local.indexed.atSCOPUS
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relation.isAuthorOfPublication.latestForDiscoveryc5254f3f-5266-410a-b0a2-bf1caa4ec629

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