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The relationship between age-related development of spike-and-wave discharges and the resistance to amygdaloid kindling in rats with genetic absence epilepsy

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dc.contributor.authorONAT, FİLİZ
dc.contributor.authorsCarcak, Nihan; Aker, Rezzan Guelhan; Oezdemir, Osman; Demiralp, Tamer; Onat, Filiz Yilmaz
dc.date.accessioned2022-03-12T17:34:27Z
dc.date.available2022-03-12T17:34:27Z
dc.date.issued2008
dc.description.abstractGenetic Absence Epilepsy Rats from Strasbourg (GAERS) are resistant to amygdaloid kindling. Since in GAERS the characteristics of spike-and-wave discharges (SWDs) change with age, we have studied the relation between SWD maturation and the development of kindling resistance. Non-epileptic Wistar rats and GAERS were stimulated in basolateral amygdala with 400 mu A at 20 min intervals until they reached stage 5 seizures or for a maximum of 36 stimulations. All of the Wistar rats, the postnatal (PN) day 20 GAERS and the (kindling-prone) subgroups of GAERS at PN30 and PN60 reached stage 5 seizures; at PN20, PN30 and PN60 kindling rates were significantly slower in GAERS compared to Wistar rats. At PN30 and PN60, 41% and 69% of GAERS, respectively, showed no stage 3, 4 or 5 seizures after 36 stimulations (kindling-resistant subgroups). The SWD maturation involves changes in spectral patterns and correlate with age-related increases in kindling resistance in GAERS. (C) 2008 Elsevier Inc. All rights reserved.
dc.identifier.doi10.1016/j.nbd.2008.07.018
dc.identifier.eissn1095-953X
dc.identifier.issn0969-9961
dc.identifier.pubmed18755276
dc.identifier.urihttps://hdl.handle.net/11424/229023
dc.identifier.wosWOS:000261602500004
dc.language.isoeng
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE
dc.relation.ispartofNEUROBIOLOGY OF DISEASE
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTemporal lobe epilepsy model
dc.subjectAbsence epilepsy model
dc.subjectGAERS
dc.subjectAmygdaloid stimulation
dc.subjectLimbic seizures
dc.subjectKindling resistance
dc.subjectELECTRICAL-STIMULATION
dc.subjectSEIZURES
dc.subjectMECHANISMS
dc.subjectMODEL
dc.subjectEXPRESSION
dc.subjectNEURONS
dc.titleThe relationship between age-related development of spike-and-wave discharges and the resistance to amygdaloid kindling in rats with genetic absence epilepsy
dc.typearticle
dspace.entity.typePublication
local.avesis.id542b9241-90c5-4e6b-9922-f22ca3c086c5
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.journal.numberofpages9
oaire.citation.endPage363
oaire.citation.issue3
oaire.citation.startPage355
oaire.citation.titleNEUROBIOLOGY OF DISEASE
oaire.citation.volume32
relation.isAuthorOfPublicationc359dea3-046f-4397-90d5-62e4bfc31869
relation.isAuthorOfPublication.latestForDiscoveryc359dea3-046f-4397-90d5-62e4bfc31869

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