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Mucus sialylation determines intestinal host-commensal homeostasis

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dc.contributor.authorÖZEN, AHMET OĞUZHAN
dc.contributor.authorBARIŞ, SAFA
dc.contributor.authorERTEM ŞAHİNOĞLU, DENİZ
dc.contributor.authorsYao Y., Kim G., Shafer S., Chen Z., Kubo S., Ji Y., Luo J., Yang W., Perner S. P., Kanellopoulou C., et al.
dc.date.accessioned2023-04-19T06:33:49Z
dc.date.available2023-04-19T06:33:49Z
dc.date.issued2022-03-31
dc.description.abstractIntestinal mucus forms the first line of defense against bacterial invasion while providing nutrition to support microbial symbiosis. How the host controls mucus barrier integrity and commensalism is unclear. We show that terminal sialylation of glycans on intestinal mucus by ST6GALNAC1 (ST6), the dominant sialyltransferase specifically expressed in goblet cells and induced by microbial pathogen-associated molecular patterns, is essential for mucus integrity and protecting against excessive bacterial proteolytic degradation. Glycoproteomic profiling and biochemical analysis of ST6 mutations identified in patients show that decreased sialylation causes defective mucus proteins and congenital inflammatory bowel disease (IBD). Mice harboring a patient ST6 mutation have compromised mucus barriers, dysbiosis, and susceptibility to intestinal inflammation. Based on our understanding of the ST6 regulatory network, we show that treatment with sialylated mucin or a Foxo3 inhibitor can ameliorate IBD.
dc.identifier.citationYao Y., Kim G., Shafer S., Chen Z., Kubo S., Ji Y., Luo J., Yang W., Perner S. P., Kanellopoulou C., et al., "Mucus sialylation determines intestinal host-commensal homeostasis.", Cell, cilt.185, sa.7, 2022
dc.identifier.doi10.1016/j.cell.2022.02.013
dc.identifier.issn0092-8674
dc.identifier.issue7
dc.identifier.startpage1172
dc.identifier.urihttps://hdl.handle.net/11424/288764
dc.identifier.volume185
dc.language.isoeng
dc.relation.ispartofCell
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectHistoloji-Embriyoloji
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectTemel Bilimler
dc.subjectMedicine
dc.subjectHealth Sciences
dc.subjectFundamental Medical Sciences
dc.subjectHistology and Embryology
dc.subjectLife Sciences
dc.subjectMolecular Biology and Genetics
dc.subjectCytogenetic
dc.subjectNatural Sciences
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectHÜCRE BİYOLOJİSİ
dc.subjectBIOCHEMISTRY & MOLECULAR BIOLOGY
dc.subjectMOLECULAR BIOLOGY & GENETICS
dc.subjectLife Sciences (LIFE)
dc.subjectCELL BIOLOGY
dc.subjectİlaç Keşfi
dc.subjectYapısal Biyoloji
dc.subjectMoleküler Biyoloji
dc.subjectKlinik Biyokimya
dc.subjectHücre Biyolojisi
dc.subjectKanser Araştırmaları
dc.subjectBiyokimya
dc.subjectYaşlanma
dc.subjectBiyokimya, Genetik ve Moleküler Biyoloji (çeşitli)
dc.subjectGenel Biyokimya, Genetik ve Moleküler Biyoloji
dc.subjectDrug Discovery
dc.subjectStructural Biology
dc.subjectMolecular Biology
dc.subjectClinical Biochemistry
dc.subjectCell Biology
dc.subjectCancer Research
dc.subjectBiochemistry
dc.subjectAging
dc.subjectBiochemistry, Genetics and Molecular Biology (miscellaneous)
dc.subjectGeneral Biochemistry, Genetics and Molecular Biology
dc.subjectdysbiosis
dc.subjectglycobiology
dc.subjecthuman genetic disease
dc.subjectinflammatory bowel disease
dc.subjectintestinal homeostasis
dc.subjectintestinal stem cells
dc.subjectmucus barrier
dc.subjectshort-chain fatty acids
dc.subjectsialylation
dc.subjectST6GalNAc1
dc.titleMucus sialylation determines intestinal host-commensal homeostasis
dc.typearticle
dspace.entity.typePublication
local.avesis.idf2fcb3f6-bb5b-470f-8a41-bd1fe7ba82af
local.indexed.atWOS
local.indexed.atPUBMED
local.indexed.atSCOPUS
relation.isAuthorOfPublication3e9c297b-e636-4836-8f61-dc9c8b7c29cf
relation.isAuthorOfPublication5b392475-f11d-44b3-b251-4fe8e6b7dbb9
relation.isAuthorOfPublicatione1f19d32-05e2-4206-864e-f3936b370d99
relation.isAuthorOfPublication.latestForDiscovery3e9c297b-e636-4836-8f61-dc9c8b7c29cf

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