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Semen reactive oxygen species levels are correlated with erectile function among chronic prostatitis/chronic pelvic pain syndrome patients

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dc.contributor.authorYÜKSEL, MERAL
dc.contributor.authorsAlkan, Ilter; Yuksel, Meral; Ozveri, Hakan; Atalay, Anil; Canat, Halil Lutfi; Culha, Mehmet Gokhan; Arabaci, Cigdem; Bozkurt, Muammer; Basar, Murad
dc.date.accessioned2022-03-12T22:27:26Z
dc.date.available2022-03-12T22:27:26Z
dc.date.issued2018
dc.description.abstractChronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) is often associated with erectile dysfunction (ED). However, the underlying pathophysiological mechanisms of ED occurrence are still unclear in patients with CP/CPPS. The aim of the study was to investigate superoxide anion (O-2(center dot-)) and total reactive oxygen species (ROS) production in semen of men with category IIIA CP/CPPS and their association with ED. This prospective study included 33 men with category IIIA CP/CPPS. Control group consisted of 13 healthy men. Total ROS and O-2(center dot-) production were assayed by luminol and lucigenin-dependent chemiluminescence (CL) methods, respectively. ED was evaluated using the IIEF-5 questionnaire. Patients with CP/CPPS had significantly higher seminal total ROS and O-2(center dot-) levels than healthy control subjects (2.9 +/- 0.5 relative light unit (RLU) vs. 2.4 +/- 0.2 RLU, p < 0.001; luminol-dependent CL and 2.5 +/- 0.4 RLU vs. 2.3 +/- 0.2 RLU, p = 0.02; lucigenin-dependent CL, respectively). Seminal O-2(center dot-) and ROS levels were negatively correlated with IIEF-5 scores (r = -0.556, r = -0.536; p < 0.001, respectively). These results may suggest O-2(center dot-)/ROS overproduction could be one of the important mechanisms in the etiology of ED development in CP/CPPS patients.
dc.identifier.doi10.1038/s41443-018-0047-1
dc.identifier.eissn1476-5489
dc.identifier.issn0955-9930
dc.identifier.pubmed30068978
dc.identifier.urihttps://hdl.handle.net/11424/235202
dc.identifier.wosWOS:000451202700009
dc.language.isoeng
dc.publisherNATURE PUBLISHING GROUP
dc.relation.ispartofINTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectINSTITUTES-OF-HEALTH
dc.subjectINTERNATIONAL INDEX
dc.subjectOXIDATIVE STRESS
dc.subjectNADPH OXIDASES
dc.subjectSEMINAL PLASMA
dc.subjectNITRIC-OXIDE
dc.subjectDYSFUNCTION
dc.subjectMEN
dc.subjectCLASSIFICATION
dc.subjectSPERMATOZOA
dc.titleSemen reactive oxygen species levels are correlated with erectile function among chronic prostatitis/chronic pelvic pain syndrome patients
dc.typearticle
dspace.entity.typePublication
local.avesis.id25bf4f28-bd5c-468b-8d7f-629c8796ff79
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages7
local.journal.quartileQ4
oaire.citation.endPage341
oaire.citation.issue6
oaire.citation.startPage335
oaire.citation.titleINTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
oaire.citation.volume30
relation.isAuthorOfPublication8b13d479-2f3b-4180-bc71-7ad5a5625f1b
relation.isAuthorOfPublication.latestForDiscovery8b13d479-2f3b-4180-bc71-7ad5a5625f1b

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