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Obestatin improves oxidative brain damage and memory dysfunction in rats induced with an epileptic seizure

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dc.contributor.authorYEGEN, BERRAK
dc.contributor.authorsKoyuncuoglu, Turkan; Vizdiklar, Caner; Uren, Dogan; Yilmaz, Hakan; Yildirim, Cagan; Atal, Sefa Semih; Akakin, Dilek; Demirci, Elif Kervancioglu; Yuksel, Meral; Yegen, Berrak C.
dc.date.accessioned2022-03-12T20:31:50Z
dc.date.available2022-03-12T20:31:50Z
dc.date.issued2017
dc.description.abstractObestatin was shown to alleviate renal, gastrointestinal and haemorrhage-induced brain injury in rats. In order to investigate the neuroprotective effects of obestatin on seizure-induced oxidative brain injury, an epileptic seizure was induced with a single intraperitoneal (i.p.) close of pentylenetetrazole (PTZ, 45 mg/kg) in male Wistar rats. Thirty minutes before the PTZ injection, rats were treated with either saline or obestatin (1 mu g/kg, i.p.). Seizure was video-taped and then evaluated by using Racine's scoring (0-5). For the assessment of memory function, passive-avoidance test was performed before seizure induction, which was repeated on the 3rd day of seizure. The rats were decapitated at the 24th or 72nd hour of seizures and brain tissues were obtained for histopathological examination and for measuring levels of malondialdehyde (MDA), glutathione (GSH), reactive oxygen radicals and myeloperoxidase (MPO) activity. Obestatin treatment reduced the average seizure score, decreased the occurrence and duration of generalized tonic-clonic seizures, presenting with a shorter latency to their onset. Increased lipid peroxidation and enhanced generation of oxygen-derived radicals detected at the post-seizure 72nd h were suppressed by the consecutive treatments of obestatin, but no changes were observed by the single obestatin treatment in the 24-h seizure group. Neuronal damage and increased GFAP immunoreactivity, observed in the hippocampal areas and cortex of PTZ-induced rats were alleviated in 3-day obestatin-treated PTZ group. PTZ-induced memory dysfunction was significantly improved in obestatin-treated PTZ group as compared to saline-treated rats. The present data indicate that obestatin ameliorated the severity of PTZ-induced seizures, improved memory dysfunction and reduced neuronal damage by limiting oxidative damage. (C) 2017 Elsevier Inc. All rights reserved.
dc.identifier.doi10.1016/j.peptides.2017.02.005
dc.identifier.eissn1873-5169
dc.identifier.issn0196-9781
dc.identifier.pubmed28223092
dc.identifier.urihttps://hdl.handle.net/11424/234332
dc.identifier.wosWOS:000399516300006
dc.language.isoeng
dc.publisherELSEVIER SCIENCE INC
dc.relation.ispartofPEPTIDES
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSeizure
dc.subjectOxidative stress
dc.subjectObestatin
dc.subjectMemory dysfunction
dc.subjectPENTYLENETETRAZOLE-INDUCED SEIZURES
dc.subjectCOGNITIVE IMPAIRMENT
dc.subjectGHRELIN
dc.subjectRECEPTOR
dc.subjectINJURY
dc.subjectMYELOPEROXIDASE
dc.subjectANTIOXIDANT
dc.subjectSTRESS
dc.subjectEPILEPTOGENESIS
dc.subjectEXPRESSION
dc.titleObestatin improves oxidative brain damage and memory dysfunction in rats induced with an epileptic seizure
dc.typearticle
dspace.entity.typePublication
local.avesis.id44f425de-811d-47fd-8f80-80342bd45629
local.import.packageSS17
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages11
local.journal.quartileQ2
oaire.citation.endPage47
oaire.citation.startPage37
oaire.citation.titlePEPTIDES
oaire.citation.volume90
relation.isAuthorOfPublicatione4eaf9ac-f8dc-4e2b-b940-895cc906790d
relation.isAuthorOfPublication.latestForDiscoverye4eaf9ac-f8dc-4e2b-b940-895cc906790d

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