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Anti-inflammatory, antioxidant and neuroprotective effects of niacin on mild traumatic brain injury in rats

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dc.contributor.authorKOYUNCUOĞLU, TÜRKAN
dc.contributor.authorAKAKIN, DİLEK
dc.contributor.authorERZİK, CAN
dc.contributor.authorYÜKSEL, MERAL
dc.contributor.authorYEGEN, BERRAK
dc.contributor.authorsOzaydin D., Bektasoglu P. K., Koyuncuoglu T., Ozkaya S. C., Koroglu A. K., AKAKIN D., ERZİK C., YÜKSEL M., YEGEN B., Gurer B.
dc.date.accessioned2023-11-06T12:21:55Z
dc.date.available2023-11-06T12:21:55Z
dc.date.issued2023-01-01
dc.description.abstractAIM: To study the effects of niacin, a water-soluble vitamin, on inflammation, oxidative stress and apoptotic processes observed after mild traumatic brain injury (TBI). MATERIAL and METHODS: A total of 25 Wistar albino male rats were randomly divided into control (n=9), TBI + Placebo group (n=9), TBI + niacin (500 mg/kg; n=7) groups. Mild TBI was performed under anesthesia by dropping a 300 g weight from a height of 1 meter onto the skull. Behavioral tests were applied before and 24 hours after TBI. Luminol and lucigenin levels and tissue cytokine levels were measured. Histopathological damage was scored in brain tissue. RESULTS: After mild TBI, luminol and lucigenin levels were increased (p<0.001), and their levels were decreased with niacin treatment (p<0.01-p<0.001). An increased score was obtained with trauma in the tail suspension test (p<0.01), showing depressive behavior. The number of entries to arms in Y-maze test were decreased in TBI group compared to pre-traumatic values (p<0.01), while discrimination (p<0.05) and recognition indices (p<0.05) in object recognition test were decreased with trauma, but niacin treatment did not change the outcomes in behavioral tests. Levels of the anti-inflammatory cytokine IL-10 were decreased with trauma, and increased with niacin treatment (p<0.05). The histological damage score was increased with trauma (p<0.001), and decreased with niacin treatment in the cortex (p<0.05), and hippocampal dentate gyrus region (p<0.01). CONCLUSION: Niacin treatment after mild TBI inhibited trauma-induced production of reactive oxygen derivatives and elevated the anti-inflammatory IL-10 level. Niacin treatment ameliorated the histopathologically evident damage.
dc.identifier.citationOzaydin D., Bektasoglu P. K., Koyuncuoglu T., Ozkaya S. C., Koroglu A. K., AKAKIN D., ERZİK C., YÜKSEL M., YEGEN B., Gurer B., "Anti-Inflammatory, Antioxidant and Neuroprotective Effects of Niacin on Mild Traumatic Brain Injury in Rats", Turkish Neurosurgery, cilt.33, sa.6, ss.1028-1037, 2023
dc.identifier.doi10.5137/1019-5149.jtn.42563-22.3
dc.identifier.endpage1037
dc.identifier.issn1019-5149
dc.identifier.issue6
dc.identifier.startpage1028
dc.identifier.urihttps://avesis.marmara.edu.tr/api/publication/db39dc68-c8e3-4022-94ca-bf4f65cd6c2e/file
dc.identifier.urihttps://hdl.handle.net/11424/294646
dc.identifier.volume33
dc.language.isoeng
dc.relation.ispartofTurkish Neurosurgery
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectNöroloji
dc.subjectCerrahi Tıp Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectMedicine
dc.subjectInternal Medicine Sciences
dc.subjectNeurology
dc.subjectSurgery Medicine Sciences
dc.subjectHealth Sciences
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectCERRAHİ
dc.subjectKLİNİK NÖROLOJİ
dc.subjectClinical Medicine (MED)
dc.subjectCLINICAL MEDICINE
dc.subjectSURGERY
dc.subjectCLINICAL NEUROLOGY
dc.subjectCerrahi
dc.subjectNöroloji (klinik)
dc.subjectSurgery
dc.subjectNeurology (clinical)
dc.subjectBrain trauma
dc.subjectNeuroprotection
dc.subjectNiacin
dc.subjectVitamin B3
dc.titleAnti-inflammatory, antioxidant and neuroprotective effects of niacin on mild traumatic brain injury in rats
dc.typearticle
dspace.entity.typePublication
local.avesis.iddb39dc68-c8e3-4022-94ca-bf4f65cd6c2e
local.indexed.atPUBMED
local.indexed.atSCOPUS
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