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Localized cortical injections of ethosuximide suppress spike-and-wave activity and reduce the resistance to kindling in genetic absence epilepsy rats (GAERS)

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dc.contributor.authorONAT, FİLİZ
dc.contributor.authorsAker, Rezzan Guelhan; Tezcan, Kutluhan; Carcak, Nihan; Sakalli, Eren; Akin, Demet; Onat, Filiz Yilmaz
dc.date.accessioned2022-03-12T16:13:35Z
dc.date.available2022-03-12T16:13:35Z
dc.date.issued2010
dc.description.abstractModels of genetic absence epilepsy are resistant to secondary generalization of focal limbic seizures. This correlates with the postnatal development of spike-and-wave discharges (SWDs), a hallmark of absence seizures arising from a cortical focus in the perioral region of somatosensory cortex. Ethosuximide injected at this site suppresses SWDs. The effect of this suppression on kindling in Genetic Absence Epilepsy Rats from Strasbourg (GAERS), has been compared for postnatal 30 day (PN30) rats having immature SWDs and adult (>4 months) rats having mature SWDs. Non-epileptic Wistar and GAERS rats were implanted with a basolateral amygdaloid stimulation electrode, bilateral injection cannulas into the cortical perioral focus, and cortical recording electrodes. Following recovery cortical injections of ethosuximide or saline were made and after 30 min rats were given 36 stimulations or until Racine's stage 5 seizures were produced. All Wistar rats (PN30 and adult) treated with saline or ethosuximide reached stage 5. Of GAERS given saline, 33% (PN30) and 43% (adults) were resistant to kindling; after ethosuximide pups behaved like Wistars, but adults showed a delay in kindling relative to Wistars. These findings imply that mechanisms underlying kindling resistance are related but not limited to SWD activity in animals with genetic absence epilepsy. (C) 2009 Elsevier B.V. All rights reserved.
dc.identifier.doi10.1016/j.eplepsyres.2009.10.013
dc.identifier.eissn1872-6844
dc.identifier.issn0920-1211
dc.identifier.pubmed19939632
dc.identifier.urihttps://hdl.handle.net/11424/224933
dc.identifier.wosWOS:000277216200003
dc.language.isoeng
dc.publisherELSEVIER
dc.relation.ispartofEPILEPSY RESEARCH
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCortical focus
dc.subjectLimbic epilepsy
dc.subjectCircuitry
dc.subjectAmygdala
dc.subjectTemporal lobe
dc.subjectSWD
dc.subjectIDIOPATHIC GENERALIZED EPILEPSY
dc.subjectTEMPORAL-LOBE
dc.subjectTHALAMIC NUCLEI
dc.subjectSEIZURES
dc.subjectMODEL
dc.subjectCOEXISTENCE
dc.subjectDISCHARGES
dc.subjectMECHANISMS
dc.subjectEXPRESSION
dc.subjectNEURONS
dc.titleLocalized cortical injections of ethosuximide suppress spike-and-wave activity and reduce the resistance to kindling in genetic absence epilepsy rats (GAERS)
dc.typeconferenceObject
dspace.entity.typePublication
local.avesis.idc12990c3-68fc-4d3d-b366-c6b8983d163a
local.conference.dateJUN 21-24, 2009
local.conference.locationPecs, HUNGARY
local.conference.sponsorInt Sch Neurol Sci
local.conference.titleAlumni Conference on San Servolo Epilepsy Courses
local.import.packageSS15
local.indexed.atWOS
local.indexed.atSCOPUS
local.indexed.atPUBMED
local.journal.numberofpages10
oaire.citation.endPage16
oaire.citation.issue1
oaire.citation.startPage7
oaire.citation.titleEPILEPSY RESEARCH
oaire.citation.volume89
relation.isAuthorOfPublicationc359dea3-046f-4397-90d5-62e4bfc31869
relation.isAuthorOfPublication.latestForDiscoveryc359dea3-046f-4397-90d5-62e4bfc31869

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